荧光素硫酸软骨素 B

Fluorescein Chondroitin sulfate B sodium salt

F758589-1mg

1mg

≥95%

硫酸皮肤素（Dermatan Sulfate，DS）也曾被误称为硫酸软骨素B，它是一类由艾杜糖醛酸（IdoUA）和N-乙酰半乳糖胺（GalNAc）组成的二糖单位（GlcUAa1-3GalNAc）通过β-1,4糖苷键重复连接而成的硫酸化GAGs。从组成和结构看，DS是完全不同于CS的一类GAGs，但从生物合成过程看，DS是在CS合成过程中，糖链中葡萄糖醛酸残基（GlcUA）在C5差像异构酶作用下转变为IdoUA残基的产物，因此CS和DS往往同时存在于同一糖链中，被称为CS-DS杂合链。大量研究表明，CS-DS糖链中的DS区通常在与蛋白的相互作用中发挥着关键作用，与CS一起参与了各种重要的生理和病理过程。目前，商品化DS主要分离自动物皮肤或肝素副产物，但由于其与理化性质高度相似的HS、CS及HA伴生，致使制备高纯度的DS较为困难。 Dermatol Sulfate (DS), also mistakenly referred to as chondroitin sulfate B, is a class of sulfated GAGs composed of disaccharide units (GlcUAa1-3GalNAc) composed of iduronic acid (IdoUA) and N-acetylgalactosamine (GalNAc) repeatedly linked by β -1,4-glycosidic bonds. From the perspective of composition and structure, DS is a type of GAGs that is completely different from CS. However, from the perspective of biosynthesis, DS is a product of the transformation of glucuronic acid residues (GlcUA) in the sugar chain into IdoUA residues under the action of C5 differential isomerase during CS synthesis. Therefore, CS and DS often coexist in the same sugar chain and are called CS-DS hybrid chains. Numerous studies have shown that the DS region in the CS-DS sugar chain typically plays a critical role in interactions with proteins and participates in various important physiological and pathological processes along with CS. At present, commercial DS mainly separates animal skin or heparin by-products, but due to its high similarity with HS, CS, and HA in physicochemical properties, it is difficult to prepare high-purity DS.