Ginsenoside F4 (GF4), ginseng saponinis, isolated from notoginseng or red ginseng. Ginsenoside F4 (GF4) has inhibitory effect on human lymphocytoma JK cell by inducing its apoptosis.Ginsenoside F4 (GF4) inhibits matrix metalloproteinase 13 (MMP 13) expression in IL-1β-treated chondrocytes and blocks cartilage breakdown in rabbit cartilage tissue culture, shows therapeutic potential for preventing cartilage collagen matrix breakdown in diseased tissues . In Vitro Ginsenoside F4 inhibits JK cell proliferation with an IC50 value of 87.74 μM. Ginsenoside F4 (8.15-130.38 μM) dose-dependently increases Bax expression but reduces Bcl-2 expression in human lymphocytoma JK cells. Ginsenoside F4 (8.15-130.38 μM) induces apoptosis in human lymphocytoma JK cells to exhibit anti-tumor activity. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: Human lymphocytoma JK cells Concentration: 8.15 μM, 65.19 μM, 130.38 μM Incubation Time: Result: Decreased Bcl-2 protein level and increased the Bax level, which changes related to apoptosis. Form:Solid