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Product introduction

Guanfu base A 是一种从 Aconitum coreanum 中分离的抗心律失常的生物碱，是一种有效的非竞争性 CYP2D6 抑制剂，对人肝微粒体 (HLM) 的 Ki 为 1.20 μM，对人重组体 (rCYP2D6) 的 Ki 为 0.37 μM。Guanfu base A 也是 CYP2D 的有效竞争抑制剂，对猴子和狗的微粒体的 Ki 分别为 0.38 μM，2.4 μM。Guanfu base A 还能抑制 HERG 通道电流。 product description： Guanfu base A is an antiarrhythmic alkaloid isolated from Aconitum coreanum and is a potent noncompetitive CYP2D6 inhibitor, with a Ki of 1.20 μM in human liver microsomes (HLMs) and a Ki of 0.37 μM for the human recombinant form (rCYP2D6). Guanfu base A is also a potent competitive inhibitor of CYP2D in monkey (Ki of 0.38 μM) and dog (Ki of 2.4 μM) microsomes. Guanfu base A also inhibits HERG channel current.

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Chinese name

关附甲素

English name

Guan-fu base A

Chinese alias

Acehytisine; Kwan-fu base A; (2alpha,11alpha,13R)-Hetisan-2,11,13,14-tetrol 2,13-diacetate

English alias

Acehytisine; Kwan-fu base A; (2alpha,11alpha,13R)-Hetisan-2,11,13,14-tetrol 2,13-diacetate

CAS number

1394-48-5

molecular formula

C24H31NO6

molecular weight

429.51 g/mol

Exact mass

≥98%

PSA

Logp

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