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Product introduction

GATA4-NKX2-5-IN-1 (Compound 3) 剂量依赖性地抑制 GATA4–NKX2-5 转录协同作用，IC50 为 3 μM。 GATA4-NKX2-5-IN-1 对参与调节 GATA4 磷酸化的蛋白激酶没有活性。GATA4-NKX2-5-IN-1 调节肥大激动剂诱导的心脏基因表达。 GATA4-NKX2-5-IN-1 (3i-1000) is a potent, dose-dependent inhibitor of the GATA4–NKX2-5 transcriptional synergy with IC50 of 3 μM. GATA4-NKX2-5-IN-1 exhibits no activity on the protein kinases involved in the regulation of GATA4 phosphorylation, and it modulates the hypertrophic agonist-induced cardiac gene expression.

Specs ⸢ View details ⸥

Chinese name

GATA4-NKX2-5-IN-1

English name

GATA4-NKX2-5-IN-1

Chinese alias

English alias

3i-1000

CAS number

544681-96-1

molecular formula

C21H23N3O2

molecular weight

349.43 g/mol

Exact mass

重组

PSA

58.400 Å²

Logp

4.100

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