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Product introduction

描述： Gefapixant (AF-219, MK-7264, R1646, RG-1646, RO 4926219) 是一种口服的人源P2X3 receptor小分子拮抗剂，对recombinant hP2X3 homotrimers 和 hP2X2/3 heterotrimeric receptors的IC50分别为约30 nM，100-250 nM。 Gefapixant具有治疗顽固性和不明原因慢性咳嗽的前景。 Information Gefapixant Gefapixant (AF-219, MK-7264, R1646, RG-1646, RO 4926219) is an orally active small molecule antagonist of human P2X3 receptor with IC50 of about 30 nM, 100–250 nM for recombinant hP2X3 homotrimers and hP2X2/3 heterotrimeric receptors , respectively. Gefapixant has shown promise for the treatment of refractory and unexplained chronic cough. Targets hP2X3 (Cell-free assay); hP2X2/3 (Cell-free assay) 30 nM; 100-250 nM

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Chinese name

格法皮克斯, P2X3 拮抗剂

English name

Gefapixant

Chinese alias

吉法匹生

English alias

5-[(2,4-Diamino-5-pyrimidinyl)oxy]-4-isopropyl-2-methoxybenzenesulfonamide | AF9 | Lopac0_000838 | DB15097 | AC-35643 | Benzenesulfonamide, 5-[(2,4-diamino-5-pyrimidinyl)oxy]-2-methoxy-4-(1-methylethyl)- | s6664 | Tox21_303065 | Gefapixant(AF-219,MK-7264)

CAS number

1015787-98-0

molecular formula

C14H19N5O4S

molecular weight

353.4 g/mol

Exact mass

PSA

165.000 Å²

Logp

1.061

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