Share to

Overview

Specs

Technical Documents

Articles

reviews

Consult

returns

Product introduction

GI254023X 是一种有效的 MMP9 和 ADAM10 抑制剂, IC50s 分别为 2.5 和 5.3 nM。 GI254023X (GI 4023, SRI028594)是ADAM10的选择性抑制剂，对ADAM10的选择性是对ADAM17的100倍。它对重组型ADAM10和ADAM17的IC50值分别为5.3 nM和541 nM IC50值: 5.3 nM (ADAM10) 去整合素金属蛋白酶10(也称为ADAM10或CDw156或 CD156c)是在人体内经ADAM10基因编码的蛋白质.ADAM10 (EC#: 3.4.24.81)是一种脱落酶,对多肽水解反应具有广泛的特异性.由GSK合成的GI 254023X 对ADAM10的抑制作用是对ADAM17的100倍.GI 254023X可减少ECV-304转染子对分形素(fractilkine)的组成型切割. 体外实验:之前的研究报道,化合物GI254023X仅对ADAM10具有可比性的抑制效力,且以减少了超过100倍的效力阻滞TACE. 体内实验:为了检验GI254023X在体内抑制Hla介导的内皮屏障破坏能力,在小鼠皮下注射重组毒素,在3天周期内给小鼠腹腔内注射GI254023X,随后进行Miles试验.结果表明,尽管所有的实验动物都死于该致命挑战,GI254023X用药的小鼠在外表看起来没那么严重,且死亡时间有所延后. 临床试验:目前GI254023X处于临床前发展阶段,还没有进行临床试验. Product Application： GI254023X has been used to inhibit ADAM10 (ADAM metallopeptidase domain 10).

Specs ⸢ View details ⸥

Chinese name

GI254023X,ADAM10金属蛋白酶抑制剂, ADAM10 抑制剂

English name

GI254023X

Chinese alias

English alias

GI4023 | AKOS025401993 | J-016226 | SCHEMBL11989235 | CCG-268545 | GI 254023X | (2r)-n-[(1s)-2,2-dimethyl-1-[(methylamino)carbonyl]-propyl]-2-[(1s)-1-[formyl(hydroxy)amino]ethyl]-5-phenylpentanamide | AC-27562 | Benzenepentanamide, N-[(1S)-2,2-dimethyl-1-

CAS number

260264-93-5

molecular formula

C21H33N3O4

molecular weight

391.5 g/mol

Exact mass

PSA

98.700 Å²

Logp

2.900

Technical Documents

「No technical documents」

「No upstream and downstream information yet」

Articles

「No related articles yet」

user reviews

Consultation

Warm reminder：

Because the manufacturer may temporarily adjust product specifications, prices, inventory, parameters and other information without notice, and there are differences in each user's consultation time and procurement needs, the platform reply content is only of reference value within a certain period. Sorry for the inconvenience caused to you, and thank you for your understanding and support! Please consult the online customer service for the latest details. Everything is subject to the real-time reply of the customer service.！

After Sales Services

Please check the quantity, appearance and product information in time when you receive the goods. In case of damage, wrong delivery, abnormal quality and other problems, please feel free to contact us.

Service Hotline:400-6226-992 ，We will handle it for you as soon as possible, thank you for your support and trust.！

GI254023X, ADAM10 inhibitor; ADAM17 inhibitor 1ml

Name: GI254023X, ADAM10 inhibitor; ADAM17 inhibitor 1ml
Brand: 阿拉丁
SKU: G422912-1ml

GI254023X, ADAM10 inhibitor; ADAM17 inhibitor 1ml; supplied for laboratory research, analysis, inspection, and scientific procurement use; specifications: 1ml.

item number：G422912-1ml

Product model：1ml

level： 1ml

Lead Time：30days

sold 410 Items

Ask Solution engineer

Specifications：

1ml

Qty

GI254023X, ADAM10 inhibitor; ADAM17 inhibitor 1ml

Recommended for you