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名称

Glabrescione B

分子类型

小分子

别名

绿泥石乙素

英文名称

Glabrescione B

货号

G646671-5mg

包装规格

5mg

浓度

≥98%

储存温度

-20°C储存

运输条件

超低温冰袋运输

产品介绍

Glabrescione B is the first compound that binds the Hedgehog (Hh) modulator Gli1 . Glabrescione B impairs its activity by interfering with Gli1-DNA interaction. Glabrescione B inhibits the growth of Hedgehog-dependent tumor cells, the self-renewal ability, and clonogenicity of tumor-derived stem cells In Vitro Glabrescione B (5 μM; 24-72 hours) inhibits the growth of Gli-dependent basal cell carcinoma. Glabrescione B (1-10 μM; 24-48 hours) decreases Gli1 mRNA expression levels. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Proliferation AssayCell Line: ASZ001 BCC cells Concentration: 5 μM Incubation Time: 24-72 hours Result: Basal cell carcinoma cell proliferation was impaired. Western Blot AnalysisCell Line: ASZ001 BCC cells Concentration: 1-10 μM Incubation Time: 24-48 hours Result: Gli1 mRNA expression levels was decreased. In Vivo Animal Model: Female NOD/SCID mice (ASZ001 BCC allografts)Dosage: 100 μmol/kg Administration: I.p.; every second day for 18 days Result: A significant reduction of tumor growth as well as Gli1 mRNA levels was observed. Form:Solid IC50& Target:Gli1-DNA Interaction

生化机理

Glabrescione B 是第一个能与刺猬（Hh）调节器 Gli1 结合的化合物。Glabrescione B 通过干扰 Gli1-DNA 的相互作用来削弱其活性。Glabrescione B 可抑制依赖刺猬蛋白的肿瘤细胞的生长和自我更新能力。

CAS号

65893-94-9

分子式

C27H30O6

分子量

450.52 g/mol

PubChem编号

44257338

Isomeric SMILES

CC(=CCOC1=C(C=C(C=C1)C2=COC3=C(C2=O)C(=CC(=C3)OC)OC)OCC=C(C)C)C

IIUPAC Name

3-[3,4-bis(3-methylbut-2-enoxy)phenyl]-5,7-dimethoxychromen-4-one

INCHI

1S/C27H30O6/c1-17(2)9-11-31-22-8-7-19(13-23(22)32-12-10-18(3)4)21-16-33-25-15-20(29-5)14-24(30-6)26(25)27(21)28/h7-10,13-16H,11-12H2,1-6H3

InChi Key

RHXDATRKLOYVTC-UHFFFAOYSA-N

Smiles

CC(=CCOC1=C(C=C(C=C1)C2=COC3=C(C2=O)C(=CC(=C3)OC)OC)OCC=C(C)C)C

PubChem CID

44257338

MeSH Entry Terms

glabrescione B

溶解性

DMSO : 100 mg/mL (221.97 mM; Need ultrasonic)

氢键供体数Hydrogen Bond Donor Count

氢键受体数Hydrogen Bond Acceptor Count

可旋转键计数Rotatable Bond Count

精确质量Exact Mass

450.204 Da

单同位素质量Monoisotopic Mass

450.204 Da

拓扑极表面积Topological Polar Surface Area

63.200 Å²

重原子数Heavy Atom Count

形式电荷Formal Charge

复杂度Complexity

746.000

同位素原子数Isotope Atom Count

共价键合单元计数Covalently-Bonded Unit Count

XLogP3

6.100

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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