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Product details

名称

GDP366

分子类型

小分子

英文名称

GDP366

货号

G646840-5mg

包装规格

5mg

浓度

≥99%

储存温度

-20°C储存

运输条件

超低温冰袋运输

产品介绍

GDP366, a dual inhibitor of survivin and Op18 , induces cell growth inhibition, cellular senescence and mitotic catastrophe in human cancer cells. In Vitro GDP366 potently and selectively inhibits the expression of both survivin and Op18. GDP366 decreass both the mRNA and protein levels of survivin and Op18. This inhibitory effect is not dependent on the status of p53 and p21 although GDP366 potently increases p53 and p21 levels. GDP366 significantly inhibits the growth of tumor cells in vitro and in vivo (nude mouse model) without rapid induction of apoptosis. GDP366 induces polyploidy in multiple types of cancer cell lines. GDP366 increases chromosomal instability, and induces cellular senescence by inhibiting telomerase activity. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:Survivin, Op18

生化机理

GDP366 是一种存活素和 Op18 的双重抑制剂，可诱导人类癌细胞的细胞生长抑制、细胞衰老和有丝分裂灾难。

CAS号

501698-03-9

分子式

C20H17N5OS

分子量

375.4 g/mol

PubChem编号

6539985

Isomeric SMILES

CC1=CC(=CC=C1)NC(=O)NC2=CC=C(C=C2)C3=CSC4=NC=NC(=C34)N

IIUPAC Name

1-[4-(4-aminothieno[2,3-d]pyrimidin-5-yl)phenyl]-3-(3-methylphenyl)urea

INCHI

1S/C20H17N5OS/c1-12-3-2-4-15(9-12)25-20(26)24-14-7-5-13(6-8-14)16-10-27-19-17(16)18(21)22-11-23-19/h2-11H,1H3,(H2,21,22,23)(H2,24,25,26)

InChi Key

DZSUJUOJJJCWGG-UHFFFAOYSA-N

Smiles

CC1=CC(=CC=C1)NC(=O)NC2=CC=C(C=C2)C3=CSC4=NC=NC(=C34)N

PubChem CID

6539985

MeSH Entry Terms

GDP 366;GDP-366;GDP366

溶解性

DMSO : 62.5 mg/mL (166.47 mM; Need ultrasonic)

氢键供体数Hydrogen Bond Donor Count

氢键受体数Hydrogen Bond Acceptor Count

可旋转键计数Rotatable Bond Count

精确质量Exact Mass

375.115 Da

单同位素质量Monoisotopic Mass

375.115 Da

拓扑极表面积Topological Polar Surface Area

121.000 Å²

重原子数Heavy Atom Count

形式电荷Formal Charge

复杂度Complexity

513

同位素原子数Isotope Atom Count

共价键合单元计数Covalently-Bonded Unit Count

XLogP3

3.8

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

user reviews

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