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Product introduction

Gemfibrozil 1-O-β-Glucuronide, a metabolite of Gemfibrozil (CI-719; HY-B0258), is a potent and competitive P450 (CYP) isoform CYP2C8 inhibitor with an IC 50 of 4.07 μM In Vitro Gemfibrozil 1-O-β-Glucuronide significantly inhibits the OATP2 (OATP1B1)-mediated uptake of Cerivastatin (CER; HY-129458) with an IC 50 of 24.3 μM. Gemfibrozil 1-O-β-Glucuronide inhibits CYP2C8-mediated M1, M23 formation with IC 50 s of 5.38 μM, 4.30 μM, and has no effects for CYP2C8-mediated M3 formation. Gemfibrozil 1-O-β-Glucuronide has an IC 50 of 243 μM for the CYP3A4- mediated metabolism. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:CYP3 CYP2C8 4.07 μM (IC 50 )

Specs ⸢ View details ⸥

Chinese name

Gemfibrozil 1-O-β-glucuronide

English name

Gemfibrozil 1-O-β-glucuronide

Chinese alias

吉非罗齐 1-O-β-葡萄糖苷酸

English alias

CAS number

91683-38-4

molecular formula

C21H30O9

molecular weight

426.46 g/mol

Exact mass

≥99%

PSA

143.000 Å²

Logp

2.200

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