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Product introduction

GNE-9278 is a highly selective positive allosteric modulator of NMDAR that acts at the GluN1 transmembrane domain (TMD). GNE-9278 acts on activated NMDARs to increase peak current and agonist affinity In Vitro GNE-9278 (50 μM) slows deactivation with multiple agonists (D-Glu, L-Glu and L-CCG-IV) and enhances the potency of both Glu and Gly. GNE-9278 robustly potentiates GluN2A, 2B, 2C and 2D-containing NMDARs as measured by calcium influx assays from HEK cell lines with EC 50 s of 0.74, 3.07, 0.47, and 0.32 μM, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:NMDAR

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Chinese name

GNE-9278

English name

GNE-9278

Chinese alias

English alias

CAS number

2315311-83-0

molecular formula

C21H27N5O3S

molecular weight

429.54 g/mol

Exact mass

≥99%

PSA

Logp

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