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Product details

名称

GSK840

分子类型

未知

别名

2-(4-(5-(甲基氨基甲酰基)-1H-苯并[d]咪唑-1-基)苯基)乙酸叔丁酯

英文别名

tert-Butyl 2-(4-(5-(methylcarbamoyl)-1H-benzo[d]imidazol-1-yl)phenyl)acetate | GSK'840

英文名称

GSK840

货号

G648461-5mg

包装规格

5mg

级别

Moligand™

浓度

≥98%

储存温度

-20°C储存

运输条件

超低温冰袋运输

产品介绍

GSK840 (GSK'840) is a receptor-interacting protein kinase 3 (RIP3 or RIPK3) inhibitor, which binds RIP3 kinase domain with an IC 50 of 0.9 nM, and inhibits kinase activity with an IC 50 of 0.3 nM In Vitro GSK840 (GSK'840) (0.01-3 μM; 24 hours) blocks TNF-induced necroptosis in a concentration-dependent manner. GSK840 binds the kinase domain and inhibits kinase activity with high specificity, targeting a broader range of pro-necrotic stimuli than can be achieved with RIP1 kinase inhibitors. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: Human HT-29 cells (TNF 10 ng/ml + zVAD-fmk 20 μM + SMAC007 100 nM) Concentration: 0.01-3 μM Incubation Time: 24 hours Result: Blocked TNF-induced necroptosis in a concentration-dependent manner. Form:Solid IC50& Target:IC50: 0.3 nM (RIP3)

生化机理

GSK840（GSK'840）是一种受体相互作用蛋白激酶 3（RIP3 或 RIPK3）抑制剂，与 RIP3 激酶结构域结合的 IC 50 为 0.9 nM，抑制激酶活性的 IC 50 为 0.3 nM。

CAS号

2361146-30-5

分子式

C21H23N3O3

分子量

365.43 g/mol

PubChem编号

138377545

Isomeric SMILES

CC(C)(C)OC(=O)CC1=CC=C(C=C1)N2C=NC3=C2C=CC(=C3)C(=O)NC

IIUPAC Name

tert-butyl 2-[4-[5-(methylcarbamoyl)benzimidazol-1-yl]phenyl]acetate

INCHI

1S/C21H23N3O3/c1-21(2,3)27-19(25)11-14-5-8-16(9-6-14)24-13-23-17-12-15(20(26)22-4)7-10-18(17)24/h5-10,12-13H,11H2,1-4H3,(H,22,26)

InChi Key

UGTLDBJIOSYXRR-UHFFFAOYSA-N

Smiles

CC(C)(C)OC(=O)CC1=CC=C(C=C1)N2C=NC3=C2C=CC(=C3)C(=O)NC

PubChem CID

138377545

溶解性

DMSO : 110 mg/mL (301.02 mM; Need ultrasonic)

氢键供体数Hydrogen Bond Donor Count

氢键受体数Hydrogen Bond Acceptor Count

可旋转键计数Rotatable Bond Count

精确质量Exact Mass

365.174 Da

单同位素质量Monoisotopic Mass

365.174 Da

拓扑极表面积Topological Polar Surface Area

73.200 Å²

重原子数Heavy Atom Count

形式电荷Formal Charge

复杂度Complexity

537.000

同位素原子数Isotope Atom Count

共价键合单元计数Covalently-Bonded Unit Count

XLogP3

3.100

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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