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Product details

名称

GNE-375

英文名称

GNE-375

货号

G648643-5mg

包装规格

5mg

浓度

≥99%

储存温度

-20°C储存

运输条件

超低温冰袋运输

产品介绍

GNE-375 is a potent and highly selective BRD9 inhibitor with an IC 50 of 5 nM. GNE-375 shows >100-fold selective for BRD9 over BRD4 , TAF1, and CECR2 . GNE-375 decreases BRD9 binding to chromatin Form:Solid IC50& Target:BRD9 5 nM (IC 50 )

生化机理

GNE-375 是一种强效、高选择性的 BRD9 抑制剂，其 IC 50 为 5 nM。GNE-375 对 BRD9 的选择性大于 BRD4、TAF1 和 CECR2 的 100 倍。GNE-375 可减少 BRD9 与染色质的结合。

CAS号

1926989-06-1

分子式

C25H29N3O5

分子量

451.51 g/mol

Smiles

O=C1C(NC(C)=C2)=C2C(C3=CC(OC)=C(C(N4CCOCC4)=O)C=C3OC)=CN1C/C=C/C

溶解性

DMSO : 50 mg/mL (110.74 mM; Need ultrasonic)

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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