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名称

GNE-1858

英文名称

GNE-1858

货号

G649232-5mg

包装规格

5mg

浓度

≥99%

储存温度

-20°C储存

运输条件

超低温冰袋运输

产品介绍

GNE-1858 is a potent and ATP-competitive hematopoietic progenitor kinase-1 (HPK1) inhibitor, with IC 50 s of 1.9 nM, 1.9 nM, and 4.5 nM for wild-type and the active mimetic mutants HPK1-TSEE and HPK1-SA, respectively. In Vitro Hematopoietic progenitor kinase-1 (HPK1), a serine/threonine Ste20-related protein kinase whose expression is restricted to the hematopoietic compartment (e.g., T cells, B cells, and dendritic cells), is one such kinase. HPK1 is a negative-feedback regulator of T cell receptor signaling, which dampens T cell proliferation and effector function. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid

生化机理

GNE-1858 是一种强效的 ATP 竞争性造血祖细胞激酶-1（HPK1）抑制剂，对野生型和活性模拟突变体 HPK1-TSEE 和 HPK1-SA 的 IC 50 s 分别为 1.9 nM、1.9 nM 和 4.5 nM。

CAS号

2680616-96-8

分子式

C21H26F2N8

分子量

428.48 g/mol

Smiles

FC1(CCN(C2=NC(C3CCNC3)=CC(NC4=CC5=C(C=N4)C=NN5C(C)C)=N2)C1)F

溶解性

DMSO : 20 mg/mL (46.68 mM; Need ultrasonic)

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

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「No related articles yet」

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