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名称

GPR40 agonist 6

分子类型

小分子

别名

GPR40 激动剂 6

英文名称

GPR40 agonist 6

货号

G650127-5mg

包装规格

5mg

浓度

≥99%

储存温度

-20°C储存

运输条件

超低温冰袋运输

产品介绍

GPR40 agonist 6 (Compound 7a) is a potent and selective free fatty acid receptor 1 ( FFAR1 or GPR40 ) agonist with an EC 50 of 0.058 μM In Vitro GPR40 agonist 6 (Compound 7a) shows a very favorable ADME profile, and shows no significant inhibition of the principal cytochrome P450 isoforms (1A2, 2C9, 2C19, 2D6 and 3A4) at 5 µM. ADME profile for GPR40 agonist 6 (Compound 7a)GPR40 agonist 6 (Compound 7a) Plasma protein binding (human) a 98.6% Aqueous solubility (PBS, pH 7.4) b 404 µM Microsomal stability (mouse, t1/2) c 434 min A-B permeability (Caco-2, cm•s -1 ) d 15.2 • 10 -6 a Each value is an average of n = 4, measured at c = 1 µM. b Each value is an average of n = 2. c Each value is an average of n = 5, measured at c = 2 µM. d Each value is an average of n = 2, measured at c = 10 µM. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:EC 50 : 0.058 μM (GPR40)

生化机理

GPR40 激动剂 6（化合物 7a）是一种强效的选择性游离脂肪酸受体 1（FFAR1 或 GPR40）激动剂，其 EC 50 为 0.058 μM。

CAS号

1798751-25-3

分子式

C20H19NO4

分子量

337.37 g/mol

Smiles

CC1=C(COC2=CC=C(CCC(O)=O)C=C2)N=C(C3=CC=CC=C3)O1

溶解性

DMSO : 125 mg/mL (370.51 mM; Need ultrasonic)

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

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「No related articles yet」

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