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Product details

名称

GSK2850163

英文名称

GSK2850163

货号

G650135-5mg

包装规格

5mg

浓度

≥98%

储存温度

-20°C储存

运输条件

超低温冰袋运输

产品介绍

GSK2850163 is a novel inhibitor of inositol-requiring enzyme-1 alpha ( IRE1α ) which can inhibit IRE1α kinase activity and RNase activity with IC 50 s of 20 and 200 nM, respectively. In Vitro GSK2850163 is a novel inhibitor of inositol-requiring enzyme-1 alpha (IRE1α) which can inhibit IRE1α kinase activity and RNase activity with IC 50 s of 20 and 200 nM, respectively. The increased autophosphorylation of IRE1α could be reduced in a dose-dependent manner by GSK2850163. Increasing concentrations of GSK2850163 are capable of reducing the increased XBP 1 transcriptional activity. Two additional kinases are weakly inhibited by GSK2850163: Ron (IC 50 =4.4 μM) and FGFR1 V561M (IC 50 =17 μM). MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Oil IC50& Target:IC50: 20 nM (IRE1α kinase activity), 200 nM (IRE1α RNase activity)

生化机理

GSK2850163 是一种新型的肌醇需要酶-1α（IRE1α）抑制剂，可抑制 IRE1α 激酶活性和 RNase 活性，IC 50 s 分别为 20 和 200 nM。

CAS号

2121989-91-9

分子式

C24H29Cl2N3O

分子量

446.41 g/mol

PubChem编号

73291790

Isomeric SMILES

CC1=CC=C(C=C1)CNC(=O)N2CCC[C@@]3(C2)CCN(C3)CC4=CC(=C(C=C4)Cl)Cl

IIUPAC Name

(5R)-2-[(3,4-dichlorophenyl)methyl]-N-[(4-methylphenyl)methyl]-2,7-diazaspiro[4.5]decane-7-carboxamide

INCHI

1S/C24H29Cl2N3O/c1-18-3-5-19(6-4-18)14-27-23(30)29-11-2-9-24(17-29)10-12-28(16-24)15-20-7-8-21(25)22(26)13-20/h3-8,13H,2,9-12,14-17H2,1H3,(H,27,30)/t24-/m1/s1

InChi Key

YFDASBFQKMHSSJ-XMMPIXPASA-N

Smiles

CC1=CC=C(C=C1)CNC(=O)N2CCCC3(C2)CCN(C3)CC4=CC(=C(C=C4)Cl)Cl

PubChem CID

73291790

溶解性

DMSO : 67.5 mg/mL (151.21 mM; Need ultrasonic) Ethanol : 50 mg/mL (112.00 mM; Need ultrasonic)

氢键供体数Hydrogen Bond Donor Count

氢键受体数Hydrogen Bond Acceptor Count

可旋转键计数Rotatable Bond Count

精确质量Exact Mass

445.169 Da

单同位素质量Monoisotopic Mass

445.169 Da

拓扑极表面积Topological Polar Surface Area

35.600 Å²

重原子数Heavy Atom Count

形式电荷Formal Charge

复杂度Complexity

583.000

同位素原子数Isotope Atom Count

共价键合单元计数Covalently-Bonded Unit Count

XLogP3

4.900

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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