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名称

GSM-1

分子类型

小分子

英文别名

4-Piperidineacetic acid, 1-((1R)-1-(4-chlorophenyl)-4-methylpentyl)-2-(4-(trifluoromethyl)phenyl)-,(2S,4R)- | SCHEMBL2855563 | (2S)-1-((.ALPHA.R)-.ALPHA.-(3-METHYLBUTYL)-4-CHLOROBENZYL)-2.ALPHA.-(4-(TRIFLUOROMETHYL)PHENYL)PIPERIDINE-4.ALPHA.-ACETIC ACID |

英文名称

GSM-1

货号

G651216-5mg

包装规格

5mg

浓度

≥98%

储存温度

-20°C储存

运输条件

超低温冰袋运输

产品介绍

GSM-1 is a potent γ-secretase modulator. GSM-1 directly targets the transmembrane domain (TMD) 1 of presenilin 1 (PS1). In Vitro GSM-1 increases the levels of Aβ 38 produced from WT APP. GSM-1 potently loweres the levels of Aβ 42 of WT APP and all the Phe mutants by ∼70–80%, even for the V44F mutant, which produced only extremely small amounts of Aβ 42. GSM-1 directly binds to the N-terminal fragment of PS1. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid

生化机理

GSM-1 是一种强效的γ-分泌酶调节剂。GSM-1 直接靶向 presenilin 1（PS1）的跨膜域（TMD）1。

CAS号

884600-68-4

分子式

C26H31ClF3NO2

分子量

481.98 g/mol

PubChem编号

57987388

Isomeric SMILES

CC(C)CC[C@H](C1=CC=C(C=C1)Cl)N2CC[C@H](C[C@H]2C3=CC=C(C=C3)C(F)(F)F)CC(=O)O

IIUPAC Name

2-[(2S,4R)-1-[(1R)-1-(4-chlorophenyl)-4-methylpentyl]-2-[4-(trifluoromethyl)phenyl]piperidin-4-yl]acetic acid

INCHI

1S/C26H31ClF3NO2/c1-17(2)3-12-23(19-6-10-22(27)11-7-19)31-14-13-18(16-25(32)33)15-24(31)20-4-8-21(9-5-20)26(28,29)30/h4-11,17-18,23-24H,3,12-16H2,1-2H3,(H,32,33)/t18-,23-,24+/m1/s1

InChi Key

VMVWLAPASRQXFL-QFWMQHCXSA-N

Smiles

CC(C)CCC(C1=CC=C(C=C1)Cl)N2CCC(CC2C3=CC=C(C=C3)C(F)(F)F)CC(=O)O

PubChem CID

57987388

关联CAS

884600-68-4

溶解性

DMSO : 100 mg/mL (207.48 mM; Need ultrasonic)

氢键供体数Hydrogen Bond Donor Count

氢键受体数Hydrogen Bond Acceptor Count

可旋转键计数Rotatable Bond Count

精确质量Exact Mass

481.2 Da

单同位素质量Monoisotopic Mass

481.2 Da

拓扑极表面积Topological Polar Surface Area

40.500 Å²

重原子数Heavy Atom Count

形式电荷Formal Charge

复杂度Complexity

613

同位素原子数Isotope Atom Count

共价键合单元计数Covalently-Bonded Unit Count

XLogP3

4.8

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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