Share to

Overview

Specs

Technical Documents

Articles

reviews

Consult

returns

Product introduction

GNE 220 (hydrochloride) is a potent and selective inhibitor of MAP4K4 , with an IC 50 of 7 nM. In Vitro GNE-220 also inhibits a few other kinases with IC 50 s of 9 nM, 476 nM and 1.1 μM for MINK (MAP4K6), DMPK and KHS1 (MAP4K5), respectively. GNE-220 alters human umbilical vein endothelial cells (HUVEC) sprout morphology. GNE-220 also reduces pERM + retraction fibres in a dose-dependent manner. GNE-220 also dose-dependently increased the number of active-INTβ1 + long focal adhesions (FAs). MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:MAP4K4 7 nM (IC 50 ) MAP4K5 9 nM (IC 50 ) MAP4K6 1.1 μM (IC 50 ) DMPK 476 nM (IC 50 )

Specs ⸢ View details ⸥

Chinese name

GNE 220 hydrochloride

English name

GNE 220 hydrochloride

Chinese alias

GNE 220 盐酸盐

English alias

CAS number

2448286-21-1

molecular formula

C25H27ClN8

molecular weight

474.99 g/mol

Exact mass

≥98%

PSA

Logp

Technical Documents

「No technical documents」

「No upstream and downstream information yet」

Articles

「No related articles yet」

user reviews

Consultation

Warm reminder：

Because the manufacturer may temporarily adjust product specifications, prices, inventory, parameters and other information without notice, and there are differences in each user's consultation time and procurement needs, the platform reply content is only of reference value within a certain period. Sorry for the inconvenience caused to you, and thank you for your understanding and support! Please consult the online customer service for the latest details. Everything is subject to the real-time reply of the customer service.！

After Sales Services

Please check the quantity, appearance and product information in time when you receive the goods. In case of damage, wrong delivery, abnormal quality and other problems, please feel free to contact us.

Service Hotline:400-6226-992 ，We will handle it for you as soon as possible, thank you for your support and trust.！