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Product details

名称

GSK-3484862

英文名称

GSK-3484862

货号

G654662-1ml

包装规格

1ml

浓度

10mM in DMSO

储存温度

-80℃储存

运输条件

超低温冰袋运输

产品介绍

GSK-3484862 is a non-covalent inhibitor for DNA methyltransferase (Dnmt1) . GSK-3484862 induces DNA hypomethylation to against cancer . GSK-3484862 mediates dramatic demethylation in murine embryonic stem cells with minimal non-specific toxicity In Vitro GSK-3484862 (0-10 µM, 6 or 14 days) induces dramatic DNA methylation loss. GSK-3484862 (0-10 µM, 4 days) results in a modest reduction in DNMT1 protein level. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: Murine embryonic stem cells (mESC, wild-type (WT) or Dnmt1/3a/3b triple knockout (TKO)) Concentration: 2 µM and 10 µM Incubation Time: 6 or 14 days Result: Induced dramatic DNA methylation loss, with global CpG methylation levels falling from near 70% in WT mESC to less than 18% after 6 days. Western Blot AnalysisCell Line: Murine embryonic stem cells (mESC, wild-type (WT) or Dnmt1/3a/3b triple knockout (TKO)) Concentration: 2 µM and 10 µM Incubation Time: 4 days Result: Resulted in a modest reduction in DNMT1 protein level. IC50& Target:DNMT1

生化机理

GSK-3484862 是 DNA 甲基转移酶 (Dnmt1) 的非共价抑制剂。GSK-3484862 可诱导 DNA 低甲基化以对抗癌症 .GSK-3484862 在小鼠胚胎干细胞中介导了显著的去甲基化作用，且非特异性毒性极低。

CAS号

2170136-65-7(DMSO)

分子式

C19H19N5OS

分子量

365.45 g/mol

Smiles

CCC1=C(C(=NC(=C1C#N)SC(C2=CC=CC=C2)C(=O)N)N(C)C)C#N

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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