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名称

Glabrescione B

别名

绿泥石乙素

英文名称

Glabrescione B

货号

G654692-1ml

包装规格

1ml

浓度

10mM in DMSO

储存温度

-80℃储存

运输条件

超低温冰袋运输

产品介绍

Glabrescione B is the first compound that binds the Hedgehog (Hh) modulator Gli1 . Glabrescione B impairs its activity by interfering with Gli1-DNA interaction. Glabrescione B inhibits the growth of Hedgehog-dependent tumor cells, the self-renewal ability, and clonogenicity of tumor-derived stem cells In Vitro Glabrescione B (5 μM; 24-72 hours) inhibits the growth of Gli-dependent basal cell carcinoma. Glabrescione B (1-10 μM; 24-48 hours) decreases Gli1 mRNA expression levels. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Proliferation AssayCell Line: ASZ001 BCC cells Concentration: 5 μM Incubation Time: 24-72 hours Result: Basal cell carcinoma cell proliferation was impaired. Western Blot AnalysisCell Line: ASZ001 BCC cells Concentration: 1-10 μM Incubation Time: 24-48 hours Result: Gli1 mRNA expression levels was decreased. In Vivo Animal Model: Female NOD/SCID mice (ASZ001 BCC allografts)Dosage: 100 μmol/kg Administration: I.p.; every second day for 18 days Result: A significant reduction of tumor growth as well as Gli1 mRNA levels was observed. IC50& Target:Gli1-DNA Interaction

生化机理

Glabrescione B 是第一个能与刺猬（Hh）调节器 Gli1 结合的化合物。Glabrescione B 通过干扰 Gli1-DNA 的相互作用来削弱其活性。Glabrescione B 可抑制依赖刺猬蛋白的肿瘤细胞的生长和自我更新能力。

CAS号

65893-94-9(DMSO)

分子式

C27H30O6

分子量

450.52 g/mol

Smiles

CC(=CCOC1=C(C=C(C=C1)C2=COC3=C(C2=O)C(=CC(=C3)OC)OC)OCC=C(C)C)C

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

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