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名称

GNE-131, Na 抑制剂 v1.1；Na 抑制剂 v1.2；Na 抑制剂 v1.5；Na 抑制剂 v1.6；Na 抑制剂 v1.7

分子类型

小分子

英文名称

GNE-131

货号

G654724-1ml

包装规格

1ml

级别

Moligand™

浓度

10mM in DMSO

储存温度

-80℃储存

运输条件

超低温冰袋运输

产品介绍

GNE-131 是有效的人类钠离子通道 NaV1.7(hNaV1.7)选择性抑制剂，IC50为 3 nM GNE-131 is a potent and selective inhibitor of human sodium channel NaV1.7 , with an IC 50 of 3 nM. In Vitro GNE-131 (Compound 13) shows moderate clearance in human liver microsomes and excellent functional activity against human NaV1.7 with an IC 50 of 0.003±0.001 μM. GNE-131 shows excellent potency, good in vitro metabolic stability. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo GNE-131 shows low in vivo clearance in mouse, rat, and dog. GNE-131 also displays excellent efficacy in a transgenic mouse model of induced pain . MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:Na v 1.7 3 nM (IC 50 )

生化机理

GNE-131 是一种强效的人类钠通道 NaV1.7 选择性抑制剂，其 IC 50 为 3 nM。

CAS号

1629063-81-5(DMSO)

分子式

C23H30N4O3S

分子量

442.57 g/mol

Smiles

C1CC1C2=CN3C(=NN=C3NS(=O)(=O)C4CC4)C=C2OCC56CC7CC(C5)CC(C7)C6

作用类型

抑制剂

作用机制

Na 抑制剂 v1.1；Na 抑制剂 v1.2；Na 抑制剂 v1.5；Na 抑制剂 v1.6；Na 抑制剂 v1.7

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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GNE-131, Na inhibitor v1. 1; Na inhibitor v1. 2; Na inhibitor v1. 5; Na inhibitor v1. 6; Na inhibitor v1. 7 1ml

Name: GNE-131, Na inhibitor v1. 1; Na inhibitor v1. 2; Na inhibitor v1. 5; Na inhibitor v1. 6; Na inhibitor v1. 7 1ml
Brand: 阿拉丁
SKU: G654724-1ml

GNE-131, Na inhibitor v1. 1; Na inhibitor v1. 2; Na inhibitor v1. 5; Na inhibitor v1. 6; Na inhibitor v1. 7 1ml; supplied for laboratory research, analysis, inspection, and scientific procurement use; specifications: 1ml.

item number：G654724-1ml

Product model：1ml

level： 1ml

Lead Time：30days

sold 500 Items

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Specifications：

1ml

Qty

GNE-131, Na inhibitor v1. 1; Na inhibitor v1. 2; Na inhibitor v1. 5; Na inhibitor v1. 6; Na inhibitor v1. 7 1ml

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