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Product introduction

GW274150 是一种选择性和高效性的 NADPH 依赖型人一氧化氮合成酶 (iNOS) (Kd=40 nM) 和大鼠诱导型一氧化氮合酶 (iNOS) 双重抑制剂。GW274150 对人和大鼠的内皮一氧化氮合酶 (eNOS) 和神经元一氧化氮合酶 (nNOS) 活性较低。在急性肺损伤炎症模型中，GW274150 表现出保护作用 GW274150 is a selective and potent dual inhibitor of NADPH-dependent human nitric oxide synthase (iNOS) (Kd=40 nM) and rat inducible nitric oxide synthase (iNOS). GW274150 showed low activity of endothelial nitric oxide synthase (eNOS) and neuronal nitric oxide synthase (nNOS) in human and rat. In an inflammatory model of acute lung injury, GW274150 showed protective effects

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Chinese name

GW274150, 一氧化氮合酶，诱导型抑制剂

English name

GW274150

Chinese alias

[2-[(1-iminoethyl) amino]ethyl]-L-homocysteine | GW-274150

English alias

(2S)-2-amino-4-({2-[(1-aminoethylidene)amino]ethyl}sulfanyl)butanoic acid | (2S)-2-amino-4-[2-(1-aminoethylideneamino)ethylsulfanyl]butanoic acid | Q27251084 | HY-12119 | (S)-4-(2-Acetimidoylamino-ethylsulfanyl)-2-amino-butyric acid | GTPL9849 | BDBM50086

CAS number

210354-22-6

molecular formula

C8H17N3O2S

molecular weight

219.30 g/mol

Exact mass

PSA

127.000 Å²

Logp

-3.3

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