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名称

GDP366

分子类型

小分子

英文名称

GDP366

货号

G654765-1ml

包装规格

1ml

浓度

10mM in DMSO

储存温度

-80℃储存

运输条件

超低温冰袋运输

产品介绍

GDP366, a dual inhibitor of survivin and Op18 , induces cell growth inhibition, cellular senescence and mitotic catastrophe in human cancer cells. In Vitro GDP366 potently and selectively inhibits the expression of both survivin and Op18. GDP366 decreass both the mRNA and protein levels of survivin and Op18. This inhibitory effect is not dependent on the status of p53 and p21 although GDP366 potently increases p53 and p21 levels. GDP366 significantly inhibits the growth of tumor cells in vitro and in vivo (nude mouse model) without rapid induction of apoptosis. GDP366 induces polyploidy in multiple types of cancer cell lines. GDP366 increases chromosomal instability, and induces cellular senescence by inhibiting telomerase activity. MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:Survivin, Op18

生化机理

GDP366 是一种存活素和 Op18 的双重抑制剂，可诱导人类癌细胞的细胞生长抑制、细胞衰老和有丝分裂灾难。

CAS号

501698-03-9(DMSO)

分子式

C20H17N5OS

分子量

375.4 g/mol

Smiles

CC1=CC(=CC=C1)NC(=O)NC2=CC=C(C=C2)C3=CSC4=NC=NC(=C34)N

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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