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Product details

名称

GW-870086

英文名称

GW-870086

货号

G655123-1ml

包装规格

1ml

浓度

10mM in DMSO

储存温度

-80℃储存

运输条件

超低温冰袋运输

产品介绍

GW-870086 is a potent anti-inflammatory agent, acting as a glucocorticoid receptor agonist, with a pIC 50 of 10.1 in A549 cells expressing NF-κB . In Vitro GW-870086 a glucocorticoid receptor agonist, inhibits NFkB reporter gene with a pIC 50 of 10.1, but shows no effect on the MMTV reporter genes in A549 cells, and has little or no activity at the oestrogen receptor, progesterone receptor, progesterone receptor, mineralocorticoid receptor or androgen receptor. GW-870086 (1 pM-1 μM) dose-dependently inhibits the L-6 release induced by TNF-α in A549 epithelial carcinoma cells and by IL-1 in MG63 osteosarcoma cells (pIC 50 s, 9.6, 10.2). GW-870086 (GW870086X; 10-100 nM) significantly increases fibronectin secretion. However, GW-870086 has no effect on MMP2 secretion, and does not increase cellular myocilin. MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:pIC50: 10.1 (glucocorticoid receptor, A549 NF-κB cells)

生化机理

GW-870086 是一种强效抗炎药物，可作为糖皮质激素受体激动剂，在表达 NF-κB 的 A549 细胞中的 pIC 50 为 10.1。

CAS号

827319-43-7(DMSO)

分子式

C31H39F2NO6

分子量

559.64 g/mol

Smiles

CC1CC2C3CC(C4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)OCC#N)OC(=O)C5C(C5(C)C)(C)C)C)O)F)C)F

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

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「No related articles yet」

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