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Product details

名称

GSK8814

英文名称

GSK8814

货号

G655188-1ml

包装规格

1ml

浓度

10mM in DMSO

储存温度

-80℃储存

运输条件

超低温冰袋运输

产品介绍

GSK8814 is a potent, selective, and ATAD2/2B bromodomain chemical probe and inhibitor, with a binding constant pK d =8.1 and a pK i =8.9 in BROMOscan. GSK8814 binds to ATAD2 and BRD4 BD1 with pIC 50 s of 7.3 and 4.6, respectively. GSK8814 shows 500-fold selectivity for ATAD2 over BRD4 BD1 IC50& Target:ATAD2 8.9 (pKi) ATAD2 8 nM (Ki) BRD4 BD1 4.6 (pIC 50 )

生化机理

GSK8814 是一种强效、选择性的 ATAD2/2B 溴链化学探针和抑制剂，其结合常数 pK d =8.1，在 BROMOscan 中 pK i =8.9。GSK8814 与 ATAD2 和 BRD4 BD1 的结合 pIC 50 s 分别为 7.3 和 4.6。GSK8814 与 ATAD2 和 BRD4 BD1 的结合 pIC 50 分别为 7.3 和 4.6。

CAS号

1997369-78-4(DMSO)

分子式

C28H35F2N5O3

分子量

527.61 g/mol

Smiles

CC1=CC(=CN=C1)C2=CN=C(C3=C2C=C(C(=O)N3)C)NC4C(CNCC4OCC5CCC(CC5)(F)F)OC

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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