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Product details

名称

G-5555 hydrochloride

别名

G-5555 盐酸盐

英文名称

G-5555 hydrochloride

货号

G658780-5mg

包装规格

5mg

浓度

≥98%

储存温度

2-8°C储存,干燥

运输条件

冰袋运输

产品介绍

G-5555 hydrochloride is a potent and selective p21-activated kinase 1 ( PAK1 ) inhibitor with a K i of 3.7 nM. Appearance:Solid In Vitro:G-5555 shows excellent kinase selectivity and inhibits only eight out of the 235 kinases tested other than PAK1 with inhibition >70%: PAK2, PAK3, KHS1, Lck, MST3, MST4, SIK2, and YSK1. The IC 50 s of G-5555 against SIK2, PAK2, KHS1, MST4, YSK1, MST3 and L In Vivo:G-5555 exhibits low blood clearance and an acceptable half-life. Good oral exposure (AUC=30 μM•h) and high oral bioavailability (F=80%) are achieved. In an H292 non-small cell lunger cancer (NSCLC) xenograft study in mice, G-5555 inhibits phosphoryla Biological Activity:G-5555 hydrochloride is a potent and selective p21-activated kinase 1 ( PAK1 ) inhibitor with a K i of 3.7 nM.

分子式

C25H26Cl2N6O3

分子量

529.42 g/mol

Smiles

ClC(C=C(C1=NC(C)=CC=C1)C=C2)=C2C3=CC4=CN=C(NC)N=C4N(C[C@@H]5OC[C@@H](N)CO5)C3=O.[H]Cl

溶解性

DMSO : 100 mg/mL (188.89 mM; Need ultrasonic) H2O : 16.67 mg/mL (31.49 mM; Need ultrasonic)

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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