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Product details

名称

GSK2945 hydrochloride

别名

GSK2945 盐酸盐

英文名称

GSK2945 hydrochloride

货号

G659004-5mg

包装规格

5mg

浓度

≥99%

储存温度

2-8°C储存,充氩

运输条件

冰袋运输

产品介绍

GSK2945 hydrochloride is a class of tertiary amine, and is a highly specific Rev-erbα / REV-ERBα (mouse/human reverse erythroblastosis virus α) antagonist with EC 50 s of 21.5 μM and 20.8 μM, respectively. GSK2945 hydrochloride enhances cholesterol 7α-hyd Appearance:Solid In Vitro:GSK2945 dose-dependently enhances the transcriptional activity of Rev-erbα and a Bmal1 (a target gene of REV-ERBs) luciferase reporter ( EC 50 of 2.05 μM). GSK2945 (20 μM; 12 hours and 24 hours; mouse and human primary hepatocytes) treatment incre In Vivo:GSK2945 (0-10mg/kg; intraperitoneal injection; twice every day; for 7 days; male C57BL/6 mice) treatment increases hepatic mouse cholesterol 7α-hydroxylase (Cyp7a1) level and lowers plasma cholesterol in wild-type mice. MCE has not independently con Biological Activity:GSK2945 hydrochloride is a class of tertiary amine, and is a highly specific Rev-erbα / REV-ERBα (mouse/human reverse erythroblastosis virus α) antagonist with EC 50 s of 21.5 μM and 20.8 μM, respectively. GSK2945 hydrochloride enhances cholesterol 7α-hyd

分子式

C20H19Cl3N2O2S

分子量

457.8 g/mol

Smiles

[H]Cl.O=[N+](C1=CC=C(CN(CC2=CC=C(Cl)C=C2C)CC3=CC=C(Cl)C=C3)S1)[O-]

溶解性

DMSO : 20.83 mg/mL (45.50 mM; Need ultrasonic)

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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