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名称

GSK-J1 lithium salt

别名

GSK-J1锂盐

英文名称

GSK-J1 lithium salt

货号

G659223-50mg

包装规格

50mg

储存温度

2-8°C储存,干燥

运输条件

冰袋运输

产品介绍

GSK-J1 lithium salt is a potent inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A , with IC 50 of 60 nM towards KDM6B. Appearance:Solid IC50& Target:IC50: 60 nM (KDM6B) In Vitro:GSK-J1 is selective for H3K27 demethylases of the KDM6 subfamily and specifically binds to endogenous JMJD3. GSK-J1 inhibits TNF-α production by human primary macrophages in an H3K27-dependent manner. GSK-J1 inhibits the demethylase activity of KDM5C Biological Activity:GSK-J1 lithium salt is a potent inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A , with IC 50 of 60 nM towards KDM6B.

分子式

C22H22LiN5O2

分子量

395.38 g/mol

Smiles

[Li]OC(CCNC1=NC(C2=NC=CC=C2)=NC(N(CC3)CCC4=C3C=CC=C4)=C1)=O

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

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「No related articles yet」

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