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Product details

名称

Gap19 TFA

别名

Gap19反式脂肪酸

英文名称

Gap19 TFA

货号

G659263-5mg

包装规格

5mg

浓度

≥99%

储存温度

干燥,-80℃储存

运输条件

超低温冰袋运输

产品介绍

Gap19 TFA, a peptide derived from nine amino acids of the Cx43 cytoplasmic loop (CL), is a potent and selective connexin 43 (Cx43) hemichannel blocker. Gap19 TFA inhibits hemichannels caused by preventing intramolecular interactions of the C-terminus (CT) Appearance:Solid IC50& Target:Cx43 Hemichannel In Vitro:Gap19 TFA (250 μM; for 30 min ) decreases mitochondrial potassium uptake. Gap19 TFA (400 μM) inhibits unitary hemichannel currents in HeLa-Cx43 cells. Gap19 TFA (100 μM) inhibits hemichannel unitary currents in ventricular cardiomyocytes. G In Vivo:Gap19 TFA (iv; 25mg/kg; 10 min before ligation) significantly reduces the infarct size by approximately one-fifth. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: C57/BL6 miceDosage: Biological Activity:Gap19 TFA, a peptide derived from nine amino acids of the Cx43 cytoplasmic loop (CL), is a potent and selective connexin 43 (Cx43) hemichannel blocker. Gap19 TFA inhibits hemichannels caused by preventing intramolecular interactions of the C-terminus (CT)

分子式

C57H97F3N14O15

分子量

1275.46 g/mol

溶解性

DMSO : 100 mg/mL (78.40 mM; Need ultrasonic) H2O : 100 mg/mL (78.40 mM; Need ultrasonic)

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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