GKA50 quarterhydrate

GKA50四分之一水合物

GKA50 quarterhydrate

G659443-5mg

5mg

-20°C储存

超低温冰袋运输

GKA50 quarterhydrate is a potent glucokinase activator ( EC 50 =33 nM at 5 mM glucose) and stimulates insulin release from mouse islets of Langerhans. GKA50 quarterhydrate is a glucose-like activator of beta-cell metabolism in rodent and human islets and Appearance:Solid In Vitro:GKA50 (0.01-100 μM; 24 hours) enhances INS-1 cell proliferation with EC 50 values ranging from 1 to 2 μM. GKA50 (1.2 μM+40 μM glucose; 2-4 days) treatment reduces apoptosis induced by chronic high glucose in INS-1 cells. GKA50 activates human gl In Vivo:GKA50 (1-30mg/kg; p.o.) gives significant glucose lowering in an oral glucose tolerance test. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: High-fat-fed obese female Zucker (fa/fa) rats Biological Activity:GKA50 quarterhydrate is a potent glucokinase activator ( EC 50 =33 nM at 5 mM glucose) and stimulates insulin release from mouse islets of Langerhans. GKA50 quarterhydrate is a glucose-like activator of beta-cell metabolism in rodent and human islets and

C26H28N2O6.1/4H2O

469.01 g/mol

O=C(C1=CC=C(NC(C2=CC(O[C@@H](C)CC3=CC=CC=C3)=CC(O[C@@H](C)COC)=C2)=O)N=C1)O.[1/4].O

DMSO : 46 mg/mL (98.08 mM; Need ultrasonic and warming)