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Product introduction

Golvatinib (E7050)是c-Met和VEGFR-2双重抑制剂，IC50分别为14 nM和16 nM，不抑制bFGF刺激的HUVEC生长(浓度高达1000 nM)。Golvatinib也能抑制多种肿瘤细胞的生长,包括MKN45\EBC-1\Hs746T和SNU-5.除此之外,golvatinib有效抑制HGF或VEGF诱导的生长,IC50值为17 nM和84 nM. 在MKN45\Hs746T\SUN-5和EBC-1肿瘤细胞系异种移植小鼠模型上,golvatinib显著抑制肿瘤的生长.在VEGF过表达的人胰腺癌细胞系KP-1 /VEGF异种移植小鼠模型中,E7050单一给药,可减少VEGFR-2的磷酸化,随后通过抑制VEGF/VEGFR-2介导的肿瘤血管生成从而抑制肿瘤的生长。

Specs ⸢ View details ⸥

Chinese name

Golvatinib (E7050),抑制剂, 血管内皮生长因子受体 2 抑制剂

English name

Golvatinib (E7050)

Chinese alias

English alias

AKOS015998189 | FT-0700410 | N~1~-{2-fluoro-4-[(2-{[4-(4-methylpiperazin-1-yl)piperidine-1-carbonyl]amino}pyridin-4-yl)oxy]phenyl}-N'~1~-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide | s2859 | UNII-516Z3YP58E | 1-N'-[2-fluoro-4-[2-[[4-(4-methylpiperazin-

CAS number

928037-13-2

molecular formula

C33H37F2N7O4

molecular weight

633.69 g/mol

Exact mass

PSA

119.000 Å²

Logp

4.1

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Golvatinib (E7050) 10mM in DMSO 1ml

Name: Golvatinib (E7050) 10mM in DMSO 1ml
Brand: 麦克林
SKU: G793884-1ml

Golvatinib (E7050) 10mM in DMSO 1ml Macklin 928037-13-2, complete specifications, for production, research, laboratory testing and inspection, digital one-stop procurement platform for scientific materials.

item number：G793884-1ml

Product model：1ml

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Lead Time：30days

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Golvatinib (E7050) 10mM in DMSO 1ml

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