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Product introduction

Product Introduction Gefitinib-based PROTAC 3 which conjugates an EGFR binding element to a VHL ligand via a linker induces degradation of EGFR and mutants with DC50 of 11.7 nM and 22.3 nM in HCC827(Exon 19 del) and H3255 (L858R) cells, respectively.

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Chinese name

基于吉非替尼的 PROTAC 3

English name

Gefitinib-based PROTAC 3

Chinese alias

基于吉非替尼的PROTAC 3 | (2S,4R)-1-((S)-2-(3-(2-((5-((4-((3-氯-4-氟苯基)氨基)-7-甲氧基喹唑啉-6-基)氧)戊基)氧)乙氧基)丙酰胺基)-3,3-二甲基丁酰基)-4-羟基-N-(4-(4-甲基噻唑-5-基)苄基)吡咯烷-2-羧酰胺

English alias

Gefitinib-based Proteolysis-targeting Chimera 3 | Iressa-based PROTAC 3 | (2S,4R)-1-((S)-2-(3-(2-((5-((4-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)pentyl)oxy)ethoxy)propanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-y

CAS number

2230821-27-7

molecular formula

C47H57ClFN7O8S

molecular weight

934.52 g/mol

Exact mass

PSA

215.000 Å²

Logp

6.900

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Gefitinib-based PROTAC 3 99% 5mg

Name: Gefitinib-based PROTAC 3 99% 5mg
Brand: 麦克林
SKU: G880271-5mg

Gefitinib-based PROTAC 3 99% 5mg CAS 2230821-27-7, complete specifications for production, research, laboratory testing and inspection; digital one-stop procurement platform for scientific materials.

item number：G880271-5mg

Product model：5mg

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Lead Time：30days

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Gefitinib-based PROTAC 3 99% 5mg

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