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Product details

名称

HOIPIN-1

英文别名

英文名称

HOIPIN-1

货号

H413434-100mg

包装规格

100mg

浓度

≥98%

储存温度

2-8°C储存,避光,充氩

运输条件

冰袋运输

敏感性

对光和湿度敏感

产品介绍

产品介绍： HOIPIN-1 (JTP-0819958) 是线性泛素链组装复合物 (LUBAC) 的选择性抑制剂 (IC 50 = 2.8 μM)，可在体外抑制由 LUBAC 介导的 NF-kB 激活 Product description： HOIPIN-1 (JTP-0819958) is a selective inhibitor of linear ubiquitin chain assembly complex (LUBAC) (IC 50=2.8) μ M) It can inhibit NF-kB activation mediated by LUBAC in vitro Information ： HOIPIN-1 (JTP-0819958, HOIP inhibitor-1) is a linear ubiquitin chain assembly complex (LUBAC) inhibitor with IC50 of 2.8 μM. HOIPIN-1 specifically generates Met1-linked linear ubiquitin chains through the ubiquitin ligase activity in HOIP, and activates the NF-kB pathway.

生化机理

HOIPIN-1（JTP-0819958，HOIP inhibitor-1）是一种线性泛素链组装复合物（LUBAC）抑制剂，其 IC50 值为 2.8 μM。HOIPIN-1 通过 HOIP 中的泛素连接酶活性特异性地生成与 Met1 连接的线性泛素链，并激活 NF-kB 通路。

分子式

C17H13NaO4

分子量

304.27 g/mol

溶解性

DMSO : 5 mg/mL (16.43 mM; 需超声)

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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