凋亡

小分子

3'-羟基紫檀茋

HY-N6002 | SCHEMBL17534875 | 4-[(1E)-2-(3,5-Dimethoxyphenyl)vinyl]benzene-1,2-diol | AMY22524 | CCG-267181 | AKOS015915121 | 3?-Hydroxypterostilbene | 3'-Hydroxypterostilbene | trans-4-[2-(3,5-dimethoxyphenyl)ethenyl]-1,2-benzenediol | C15837 | 4-((e)-2-(

3'-Hydroxypterostilbene

H424135-1ml

1ml

10mM in DMSO

避光,-80℃储存

超低温冰袋运输

对光线敏感

Information 3'-Hydroxypterostilbene 3'-Hydroxypterostilbene (3'-HPT) is one of the active constituents of Sphaerophysa salsula and Pterocarpus marsupium which may be useful in treating different types of haematological malignancies. 3'-Hydroxypterostilbene, a natural pterostilbene analogue, effectively inhibits the growth of human colon cancer cells (IC50s of 9.0, 40.2, and 70.9 µM for COLO 205, HCT-116, and HT-29 cells, respectively) by inducing apoptosis and autophagy. 3'-Hydroxypterostilbene inhibits the PI3K/Akt/mTOR/p70S6K, and p38MAPK pathways and activates the ERK1/2, JNK1/2 MAPK pathways. Targets p70S6K ; p38MAPK In vitro 3\'-Hydroxypterostilbene decreases cell growth in cultured human colon cancer cells (COLO 205, HCT-116, and HT-29) in a dose-dependent manner, with IC50 values of 9.0, 40.2, and 70.9 µM, respectively. 3\'-Hydroxypterostilbene effectively inhibits the growth of human colon cancer cells by inducing apoptosis and autophagy. Treatment with HPSB causes reduction of mitochondrial membrane potential and induction of caspase-3 and caspage-9, which is associated with the degradation of DFF-45 and PARP, precedes the onset of apoptosis. It significantly down-regulates phosphatidylinositol 3-kinase (PI3K)/Akt and mitogen-activated protein kinases (MAPKs) signalings including decreased the phosphorylation of mammalian target of rapamycin (mTOR). In vivo 3\'-Hydroxypterostilbene by i.p. injection has anti-tumor efficacy gainst colon cancer through the inhibition of inflammation, metastasis, and angiogenesis as well as through the induction of apoptosis. Cell Research(from reference) Cell lines：COLO 205 cells Concentrations：5-100 µM Incubation Time：24 h

3'-Hydroxypterostilbene (3'-HPT) 是 Sphaerophysa salsula 和 Pterocarpus marsupium 的活性成分之一，可用于治疗不同类型的血液恶性肿瘤。3'-Hydroxypterostilbene 是一种天然紫檀芪类似物，可通过诱导细胞凋亡和自噬，有效抑制人结肠癌细胞的生长（对 COLO 205、HCT-116 和 HT-29 细胞的 IC50 值分别为 9.0、40.2 和 70.9 µM）。3'-Hydroxypterostilbene 可抑制 PI3K/Akt/mTOR/p70S6K 和 p38MAPK 通路，并激活 ERK1/2 和 JNK1/2 MAPK 通路。

475231-21-1

C16H16O4

272.30 g/mol

10038868

COC1=CC(=CC(=C1)/C=C/C2=CC(=C(C=C2)O)O)OC

4-[(E)-2-(3,5-dimethoxyphenyl)ethenyl]benzene-1,2-diol

1S/C16H16O4/c1-19-13-7-12(8-14(10-13)20-2)4-3-11-5-6-15(17)16(18)9-11/h3-10,17-18H,1-2H3/b4-3+

UQRBFXIUUDJHSN-ONEGZZNKSA-N

COC1=CC(=CC(=C1)C=CC2=CC(=C(C=C2)O)O)OC

2

4

4

272.105 Da

272.105 Da

58.900 Ų

20

0

306.000

0

1

3.500

52596319