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Product details

名称

HSP70-IN-1

分子类型

小分子

别名

HSP70-合一

英文名称

HSP70-IN-1

货号

H648852-5mg

包装规格

5mg

浓度

≥98%

储存温度

-20°C储存

运输条件

超低温冰袋运输

产品介绍

HSP70-IN-1 is a heat shock protein ( HSP ) inhibitor; inhibits the growth of Kasumi-1 cells with an IC 50 of 2.3 μM. In Vitro The heat shock protein 70 (Hsp70) is a molecular chaperone which plays an important function in protein homeostasis as well as in cell signaling and survival. Hsp70 is frequently overexpressed in cancer, where the elevated expression is furthermore believed to be a cause of or to lead to resistance to chemotherapy and other treatments. HSP70-IN-1 interferes with the formation of functional Hsp70-HOP-Hsp90 machinery by its ability to dose-dependently alter the megacomplex components and to destabilize an Hsp70-Hsp90 machinery client, Raf-1. In cells, the refolding of heat-denatured luciferase by endogenous as well as transfected Hsp70 is inhibited by HSP70-IN-1. HSP70-IN-1 also results in induction of apoptosis in cancer cells. Addition of HSP70-IN-1to cancer cells dose-dependently alters the formation of the Hsp70-HOP complex, a phenomenon associated with their destabilization and reduction in half-life. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:HSP70 Caspase-3/7 1.9 μM (IC 50 , MOLM13 cells)

生化机理

HSP70-IN-1 是一种热休克蛋白（HSP）抑制剂；可抑制 Kasumi-1 细胞的生长，IC50 为 2.3 μM。

CAS号

1268273-90-0

分子式

C24H28N6O2S

分子量

464.58 g/mol

PubChem编号

66973893

Isomeric SMILES

CN1CCN(CC1)C2=NC=C(C(=N2)OCC3=CC=CC=C3)SC4=CC=CC(=C4)NC(=O)CN

IIUPAC Name

2-amino-N-[3-[2-(4-methylpiperazin-1-yl)-4-phenylmethoxypyrimidin-5-yl]sulfanylphenyl]acetamide

INCHI

1S/C24H28N6O2S/c1-29-10-12-30(13-11-29)24-26-16-21(23(28-24)32-17-18-6-3-2-4-7-18)33-20-9-5-8-19(14-20)27-22(31)15-25/h2-9,14,16H,10-13,15,17,25H2,1H3,(H,27,31)

InChi Key

LBJCUDZMNPAWPX-UHFFFAOYSA-N

Smiles

CN1CCN(CC1)C2=NC=C(C(=N2)OCC3=CC=CC=C3)SC4=CC=CC(=C4)NC(=O)CN

PubChem CID

66973893

溶解性

DMSO : 50 mg/mL (107.62 mM; Need ultrasonic)

氢键供体数Hydrogen Bond Donor Count

氢键受体数Hydrogen Bond Acceptor Count

可旋转键计数Rotatable Bond Count

精确质量Exact Mass

464.199 Da

单同位素质量Monoisotopic Mass

464.199 Da

拓扑极表面积Topological Polar Surface Area

122.000 Å²

重原子数Heavy Atom Count

形式电荷Formal Charge

复杂度Complexity

600

同位素原子数Isotope Atom Count

共价键合单元计数Covalently-Bonded Unit Count

XLogP3

2.6

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

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「No related articles yet」

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