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名称

HPN-01

分子类型

小分子

英文名称

HPN-01

货号

H648948-5mg

包装规格

5mg

浓度

≥98%

储存温度

-20°C储存

运输条件

超低温冰袋运输

产品介绍

HPN-01 is a potent and selective IKK inhibitor, with pIC 50 values of 6.4, 7.0 and In Vitro HPN-01 effectively suppress LPS-stimulated secretion of TNF-α, IL-1β, and IL-6 from human PBMCs (pIC 50 =6.1, 6.4, and 5.7, respectively). HPN-01 also inhibits TNF-α-induced NF-κB nuclear translocation in human lung fibroblast cells (pIC 50 =5.7). HPN-01 inhibits the expression of SREBP-1and SREBP-2 in cultured primary human hepatocytes with IC 50 s of 1.71 μΜ and 3.43 μΜ, respectively. HPN-01 is being development for the treatment of nonalcoholic fatty liver disease (NAFLD). MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:IKK-α 6.4 (pIC 50 ) IKK-β 7.0 (pIC 50 ) IKK-ε

生化机理

HPN-01 是一种强效的选择性 IKK 抑制剂，对 IKK-α 、IKK-β 和 IKK-ε 的 pIC 50 值分别为 6.4、7.0 和 <4.8。HPN-01对其他50多种激酶（包括ALK5、CDK-2、表皮生长因子受体（EGFR）、ErbB2）具有50倍以上的选择性。

CAS号

928655-63-4

分子式

C19H16ClN3O3S

分子量

401.87 g/mol

PubChem编号

15979284

Isomeric SMILES

C1=CC(=CC=C1C2=C(C(=CC(=C2)C3=CC=C(C=C3)Cl)C(=O)N)N)S(=O)(=O)N

IIUPAC Name

2-amino-5-(4-chlorophenyl)-3-(4-sulfamoylphenyl)benzamide

INCHI

1S/C19H16ClN3O3S/c20-14-5-1-11(2-6-14)13-9-16(18(21)17(10-13)19(22)24)12-3-7-15(8-4-12)27(23,25)26/h1-10H,21H2,(H2,22,24)(H2,23,25,26)

InChi Key

XJLFMRGTLRIXDT-UHFFFAOYSA-N

Smiles

C1=CC(=CC=C1C2=C(C(=CC(=C2)C3=CC=C(C=C3)Cl)C(=O)N)N)S(=O)(=O)N

PubChem CID

15979284

溶解性

DMSO : 100 mg/mL (248.84 mM; Need ultrasonic)

氢键供体数Hydrogen Bond Donor Count

氢键受体数Hydrogen Bond Acceptor Count

可旋转键计数Rotatable Bond Count

精确质量Exact Mass

401.06 Da

单同位素质量Monoisotopic Mass

401.06 Da

拓扑极表面积Topological Polar Surface Area

138.000 Å²

重原子数Heavy Atom Count

形式电荷Formal Charge

复杂度Complexity

623.000

同位素原子数Isotope Atom Count

共价键合单元计数Covalently-Bonded Unit Count

XLogP3

3.100

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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