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名称

HSP27 inhibitor J2

分子类型

小分子

别名

HSP27 抑制剂 J2

英文名称

HSP27 inhibitor J2

货号

H650076-5mg

包装规格

5mg

浓度

≥99%

储存温度

-20°C储存

运输条件

超低温冰袋运输

产品介绍

HSP27 inhibitor J2 (J2) is a HSP27 inhibitor, which significantly induces abnormal HSP27 dimer formation and inhibits a production of HSP27 giant polymers , thereby having an effect of inhibiting a chaperone function of the HSP27 and reducing a cell protection function thereof. HSP27 inhibitor J2 (J2) remarkably enhances the antiproliferative activity of 17-AAG and sensitizes cisplatin-induced lung cancer cell growth inhibition In Vitro HSP27 inhibitor J2 (10 μM; 12 h) induces significant abnormal HSP27 dimer formation in NCI-H460. ?\nHSP27 inhibitor J2 (10 μM; 24 h) increases 17-AAG-induced apoptosis in shCTRL cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:HSP27

生化机理

HSP27 抑制剂 J2（J2）是一种 HSP27 抑制剂，它能显著诱导 HSP27 二聚体的异常形成并抑制 HSP27 巨型聚合物的产生，从而具有抑制 HSP27 的伴侣功能和减少细胞蛋白的作用。

CAS号

2133499-85-9

分子式

C13H12O4S

分子量

264.3 g/mol

PubChem编号

135384973

Isomeric SMILES

CC1=CC(=O)C2=C(C=C(C=C2O1)OCC3CS3)O

IIUPAC Name

5-hydroxy-2-methyl-7-(thiiran-2-ylmethoxy)chromen-4-one

INCHI

1S/C13H12O4S/c1-7-2-10(14)13-11(15)3-8(4-12(13)17-7)16-5-9-6-18-9/h2-4,9,15H,5-6H2,1H3

InChi Key

VDCWAGBPDCXRDU-UHFFFAOYSA-N

Smiles

CC1=CC(=O)C2=C(C=C(C=C2O1)OCC3CS3)O

PubChem CID

135384973

溶解性

DMSO : 20 mg/mL (75.67 mM; Need ultrasonic)

氢键供体数Hydrogen Bond Donor Count

氢键受体数Hydrogen Bond Acceptor Count

可旋转键计数Rotatable Bond Count

精确质量Exact Mass

264.046 Da

单同位素质量Monoisotopic Mass

264.046 Da

拓扑极表面积Topological Polar Surface Area

81.100 Å²

重原子数Heavy Atom Count

形式电荷Formal Charge

复杂度Complexity

381.000

同位素原子数Isotope Atom Count

共价键合单元计数Covalently-Bonded Unit Count

XLogP3

1.600

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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