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Product details

名称

HM03

分子类型

小分子

英文名称

HM03

货号

H651975-5mg

包装规格

5mg

浓度

≥99%

储存温度

-20°C储存

运输条件

超低温冰袋运输

产品介绍

HM03 is a potent and selective HSPA5 (Heat shock 70kDa protein 5, also known as Bip, Grp78) inhibitor. HM03 has anticancer activity In Vitro HM03 (0.1-50 μM; 72 hours) exhibits over 50% inhibition at 25 μM concentration in HCT116 cells. ?\nHM03 forms more binding interactions with HSPA5 and HSPA9 than with the other HSP70 proteins. ?\nHM03 exhibits promising inhibition activities from cancer cell viability and tumor inhibition assays. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: HCT116 cells Concentration: 0.1, 1, 10, 25, 50 μM Incubation Time: 72 hours Result: Exhibited prominent inhibition effect (18% survival at 25 µM). Form:Solid IC50& Target:HSPA5

生化机理

HM03 是一种强效的选择性 HSPA5（热休克 70kDa 蛋白 5，又称 Bip、GRP78）抑制剂。HM03 具有抗癌活性。

CAS号

500565-15-1

分子式

C26H27ClN4O2

分子量

462.97 g/mol

PubChem编号

421105

Isomeric SMILES

CN1CCN(CC1)CC2=C(C=CC(=C2)NC3=C4C=C(C=CC4=NC5=C3C=CC(=C5)Cl)OC)O

IIUPAC Name

4-[(6-chloro-2-methoxyacridin-9-yl)amino]-2-[(4-methylpiperazin-1-yl)methyl]phenol

INCHI

1S/C26H27ClN4O2/c1-30-9-11-31(12-10-30)16-17-13-19(4-8-25(17)32)28-26-21-6-3-18(27)14-24(21)29-23-7-5-20(33-2)15-22(23)26/h3-8,13-15,32H,9-12,16H2,1-2H3,(H,28,29)

InChi Key

SUSDGTMJKOGWSZ-UHFFFAOYSA-N

Smiles

CN1CCN(CC1)CC2=C(C=CC(=C2)NC3=C4C=C(C=CC4=NC5=C3C=CC(=C5)Cl)OC)O

PubChem CID

421105

溶解性

DMSO : 125 mg/mL (270.00 mM; Need ultrasonic)

氢键供体数Hydrogen Bond Donor Count

氢键受体数Hydrogen Bond Acceptor Count

可旋转键计数Rotatable Bond Count

精确质量Exact Mass

462.182 Da

单同位素质量Monoisotopic Mass

462.182 Da

拓扑极表面积Topological Polar Surface Area

60.900 Å²

重原子数Heavy Atom Count

形式电荷Formal Charge

复杂度Complexity

633.000

同位素原子数Isotope Atom Count

共价键合单元计数Covalently-Bonded Unit Count

XLogP3

5.000

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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