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Product details

名称

HQ461

英文名称

HQ461

货号

H654832-1ml

包装规格

1ml

浓度

10mM in DMSO

储存温度

-80℃储存

运输条件

超低温冰袋运输

产品介绍

HQ461 is a molecular glue that promotes CDK12-DDB1 interaction to trigger cyclin K degradation. HQ461-mediated degradation of cyclin K impairs CDK12 function, resulting in decreased CDK12 substrate phosphorylation, downregulation of DNA damage response genes, and cell death.

生化机理

HQ461 是一种分子胶，可促进 CDK12-DDB1 相互作用，引发细胞周期蛋白 K 降解。HQ461 介导的细胞周期蛋白 K 降解会损害 CDK12 的功能，导致 CDK12 底物磷酸化减少、DNA 损伤反应基因的下调。

CAS号

1226443-41-9(DMSO)

分子式

C15H15N5OS2

分子量

345.44 g/mol

Smiles

O=C(NC1=NC=C(C)S1)CC2=CSC(NC3=NC(C)=CC=C3)=N2

CMGC

包含CDK，MAPK，GSK3，CLK家族

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

user reviews

Consultation

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