hGPR91 antagonist 1

小分子

hGPR91 拮抗剂 1

hGPR91 antagonist 1

H655892-1ml

1ml

10mM in DMSO

-80℃储存

超低温冰袋运输

HGPR91 antagonist 1 is a potent and selective small molecule hGPR91 antagonist with an IC 50 of 7 μM In Vivo HGPR91 antagonist 1 leads to 59, 76% inhibition of ΔMAP at 2, 4 hours and has shown rat plasma protein binding 99%. HGPR91 antagonist 1 has engaged the target under the in vivo condition. HGPR91 antagonist 1 has clearance (CL) of 0.2 nmol/min/mg of RLM . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Wistar rats Dosage: 100 mg/kg Administration: I.p.; 2 and 4 hours Result: Led to 59 and 76% inhibition of ΔMAP at 2 and 4 hours. IC50& Target:IC50: 7 μM (HGPR91)

HGPR91 拮抗剂 1 是一种强效的选择性小分子 hGPR91 拮抗剂，其 IC 50 为 7 μM。

1314796-00-3(DMSO)

C31H23F4N3O

529.53 g/mol

CC(C1=CC=C(C=C1)C2=CC(=C(C=C2)F)C(F)(F)F)NC(=O)CC3=CC=C(C=C3)C4=NC5=C(C=CC=N5)C=C4