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名称

HSP27 inhibitor J2

别名

HSP27 抑制剂 J2

英文名称

HSP27 inhibitor J2

货号

H656123-1ml

包装规格

1ml

浓度

10mM in DMSO

储存温度

-80℃储存

运输条件

超低温冰袋运输

产品介绍

HSP27 inhibitor J2 (J2) is a HSP27 inhibitor, which significantly induces abnormal HSP27 dimer formation and inhibits a production of HSP27 giant polymers , thereby having an effect of inhibiting a chaperone function of the HSP27 and reducing a cell protection function thereof. HSP27 inhibitor J2 (J2) remarkably enhances the antiproliferative activity of 17-AAG and sensitizes cisplatin-induced lung cancer cell growth inhibition In Vitro HSP27 inhibitor J2 (10 μM; 12 h) induces significant abnormal HSP27 dimer formation in NCI-H460. ?\nHSP27 inhibitor J2 (10 μM; 24 h) increases 17-AAG-induced apoptosis in shCTRL cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:HSP27

生化机理

HSP27 抑制剂 J2（J2）是一种 HSP27 抑制剂，它能显著诱导 HSP27 二聚体的异常形成并抑制 HSP27 巨型聚合物的产生，从而具有抑制 HSP27 的伴侣功能和减少细胞蛋白的作用。

CAS号

2133499-85-9(DMSO)

分子式

C13H12O4S

分子量

264.3 g/mol

Smiles

CC1=CC(=O)C2=C(C=C(C=C2O1)OCC3CS3)O

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

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