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Product details

名称

HOIPIN-8

别名

海品-8

英文名称

HOIPIN-8

货号

H658795-5mg

包装规格

5mg

浓度

≥95%

储存温度

避光,-20°C储存,干燥

运输条件

超低温冰袋运输

产品介绍

HOIPIN-8是线性泛素链组装复合物（LUBAC）的强效抑制剂，IC 50为11 nM。HOIPIN-8是一种HOIPIN-1衍生物，在小LUBAC抑制中的效力提高了255倍，在LUBAC-和TNF-α中的效力分别提高了10倍和4倍体外实验： HOIPIN-8（0-100μM；72小时）对A549无细胞毒性，IC 50值为100μMHOIPIN-8（0-10μM；24小时）对NF-κB的保护作用比HOIPIN-1高10倍，IC 50值为0.42μM HEK293T细胞HOIPIN-8（0-30μM；NF-κB荧光蛋白报告，18小时随后使用10 ng/mL TNF-α检测6小时，HOIPIN-1效力提高4倍，IC 50值生物活性： HOIPIN-8是线性泛素链组装复合物（LUBAC）的强效抑制剂，IC 50为11 nM。HOIPIN-8是一种HOIPIN-1衍生物，在小LUBAC抑制中的效力提高了255倍，在LUBAC-和TNF-α中的效力分别提高了10倍和4倍

分子式

C23H15F2N4NaO3

分子量

456.38 g/mol

Smiles

O=C(O[Na])C1=CC=C(C2=CN(C)N=C2)C=C1/C=C/C(C3=C(F)C=C(C4=CNN=C4)C=C3F)=O

溶解性

DMSO : 100 mg/mL (219.12 mM; Need ultrasonic)

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

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