Heparanase-1 pre-activated human

H755414-10μg

10μg

重组

expressed in HEK 293 cells

Recombinant human heparanase-1 is expressed in human HEK 293 cells as an active heterodimer glycoprotein containing a 50 kDa subunit and a 8 kDa subunit. This protein is manufactured in human cells, with no serum. The human cells expression system allows human-like glycosylation and folding, and often supports higher specific activity of the protein. The protein is produced with no artificial tags. Recombinant human heparanase-1 is expressed in human HEK 293 cells as an active heterodimer glycoprotein containing a 50 kDa subunit and a 8 kDa subunit. This protein is manufactured in human cells, with no serum. The human cells expression system allows human-like glycosylation and folding, and often supports higher specific activity of the protein. The protein is produced with no artificial tags.

肝素酶-1（heparanase-1）是唯一能降解硫酸肝素的内糖苷酶。它参与多种生物过程的调控，这些过程会增加肿瘤的生长、转移、血管生成和炎症。肝素酶参与 ECM 重塑和与硫酸肝素相关的生物分子（包括细胞因子和生长因子）的释放。肝素酶可将硫酸肝素蛋白聚糖的硫酸肝素侧链裂解为 10-20 个糖单位的片段。 肝素酶最初翻译为含有信号肽的前酶。信号序列的裂解产生了潜伏的 65 kDa 原肝素酶，它必须经过进一步加工才能具有活性。成熟的活性肝素酶是由 N 端 8 kDa 亚基和 C 端 50 kDa 亚基组成的异源二聚体。