Share to

Overview

Specs

Technical Documents

Articles

reviews

Consult

returns

Product introduction

依立替康，能被组织羧酸酯酶转化为7 -乙基- 10 -羟基喜树碱（Sn - 38），该产物是一种强力的DNA拓扑异构酶I抑制剂。它的行动是由UDP葡萄糖醛酸转移酶1A1 (UGT1A1). 的葡萄糖醛酸化而终止。盐酸伊立替康已使用于： •与5-氟尿嘧啶联用，筛选MDA-MB-231乳腺癌细胞中的生长抑制功能。 •在对高级别阑尾（HGA）和低级别阑尾（LGA）类器官的化学敏感性筛选中。 •与HT29结肠癌细胞中的热休克蛋白抑制剂（HPSC1）结合用作细胞毒性研究中的化学治疗剂。 Irinotecan hydrochloride has been used: • in combination with 5-fluorouracil for screening growth inhibitory functionality in MDA-MB-231 breast cancer cells. • in chemosensitivity screening of high-grade appendiceal (HGA) and low-grade appendiceal (LGA) organoids. • as a chemotherapeutic agent in the cytotoxicity studies in combination with heat shock proteins inhibitors (HPSC1) in HT29 colon cancer cells.

Specs ⸢ View details ⸥

Chinese name

伊立替康盐酸盐

English name

Irinotecan hydrochloride

Chinese alias

盐酸伊立替康 | (S)-4,11-二乙基-3,4,12,14-四氢-4-羟基-3,14-二氧代-1H-吡喃并[3',4':6,7]中氮茚并[1,2-b]喹啉-9-基酯 | CPT-11, [1,4'-联吡啶]-1'-羧酸

English alias

CAS number

100286-90-6

molecular formula

C33H38N4O6 · HCl

molecular weight

623.14 g/mol

Exact mass

10mM in DMSO

PSA

113.000 Å²

Logp

Technical Documents

「No technical documents」

「No upstream and downstream information yet」

Articles

「No related articles yet」

user reviews

Consultation

Warm reminder：

Because the manufacturer may temporarily adjust product specifications, prices, inventory, parameters and other information without notice, and there are differences in each user's consultation time and procurement needs, the platform reply content is only of reference value within a certain period. Sorry for the inconvenience caused to you, and thank you for your understanding and support! Please consult the online customer service for the latest details. Everything is subject to the real-time reply of the customer service.！

After Sales Services

Please check the quantity, appearance and product information in time when you receive the goods. In case of damage, wrong delivery, abnormal quality and other problems, please feel free to contact us.

Service Hotline:400-6226-992 ，We will handle it for you as soon as possible, thank you for your support and trust.！