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Product details

名称

IM156

分子类型

小分子

英文别名

EX-A4660 | s9604 | HL271 | Lixumistat | SCHEMBL15830992 | A936270 | AKOS040759445 | N-(Imino((4-(trifluoromethoxy)phenyl)amino)methyl)-1-pyrrolidinecarboximidamide | HL156A free base | HL-156A free base | IM156 | HY-136093B | N'-[N'-[4-(trifluoromethoxy)p

英文名称

IM156

货号

I421566-1ml

包装规格

1ml

浓度

10mM in DMSO

储存温度

-80℃储存

运输条件

超低温冰袋运输

产品介绍

M156 (HL156A)，一种二甲双胍衍生物，也是 AMPK 的有效激活剂，可增强AMPK磷酸化。IM156 可通过抑制 complex I 来阻止 oxidative phosphorylation (OXPHOS)，并增加细胞凋亡。IM156 可改善各种类型的纤维化并抑制肿瘤。 Information IM156 IM156 (HL156A), a metformin derivative, is a potent activator of AMPK that increases AMPK phosphorylation. IM156 blocks oxidative phosphorylation (OXPHOS) through the inhibition of complex I and increases apoptosis . IM156 ameliorates various types of fibrosis and inhibits tumors. Targets AMPK ; OXPHOS In vitro IM156 (HL156A) treatment of RPMCs inhibits HG-induced myofibroblast transdifferentiation and markers of epithelial-mesenchymal transition (EMT). Moreover, IM156 (HL156A) ameliorates HG-induced transforming growth factor-β1, Smad3, Snail, and fibronectin expression in the RPMCs via AMPK upregulation. IM156 treatment decreases complex I-dependent NADH oxidation in a significant, dose-dependent manner. In vivo In vivo treatment of IM156 exacerbated the memory differentiation of virus-specific CD8+ T cells results in an increase in short-lived effector cells but decrease in memory precursor effector cells. Thus, IM156 treatment impaires the function of virus-specific memory CD8+ T cells, indicating that excessive AMPK activation weakens memory T cell differentiation, thereby suppressing recall immune responses. Cell Research(from reference) Cell lines：Rat peritoneal mesothelial cells (RPMCs) Concentrations：10 μM, 30 μM, 50 μM Incubation Time：24 h

生化机理

二甲双胍衍生物 IM156（HL156A）是一种强效的 AMPK 激活剂，可增加 AMPK 磷酸化。IM156 通过抑制复合体 I 阻断氧化磷酸化（OXPHOS），增加细胞凋亡。IM156 可改善各种类型的纤维化并抑制肿瘤。

CAS号

1422365-93-2

分子式

C13H16F3N5O

分子量

315.29 g/mol

PubChem编号

71512108

Isomeric SMILES

C1CCN(C1)/C(=N/C(=NC2=CC=C(C=C2)OC(F)(F)F)N)/N

IIUPAC Name

N'-[N'-[4-(trifluoromethoxy)phenyl]carbamimidoyl]pyrrolidine-1-carboximidamide

INCHI

1S/C13H16F3N5O/c14-13(15,16)22-10-5-3-9(4-6-10)19-11(17)20-12(18)21-7-1-2-8-21/h3-6H,1-2,7-8H2,(H4,17,18,19,20)

InChi Key

NGFUHJWVBKTNOE-UHFFFAOYSA-N

Smiles

C1CCN(C1)C(=NC(=NC2=CC=C(C=C2)OC(F)(F)F)N)N

PubChem CID

71512108

氢键供体数Hydrogen Bond Donor Count

氢键受体数Hydrogen Bond Acceptor Count

可旋转键计数Rotatable Bond Count

精确质量Exact Mass

315.131 Da

单同位素质量Monoisotopic Mass

315.131 Da

拓扑极表面积Topological Polar Surface Area

89.200 Å²

重原子数Heavy Atom Count

形式电荷Formal Charge

复杂度Complexity

424.000

同位素原子数Isotope Atom Count

共价键合单元计数Covalently-Bonded Unit Count

XLogP3

2.100

ALogP

3.622

DMSO(mg / mL) Max Solubility

DMSO(mM) Max Solubility

199.816042373688

Water(mg / mL) Max Solubility

＜1

HBD Count

Rotatable Bond

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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