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Product details

名称

欧前胡素

分子类型

小分子

别名

英文别名

英文名称

Imperatorin

货号

I424190-1ml

包装规格

1ml

浓度

10mM in DMSO

储存温度

-80℃储存

运输条件

超低温冰袋运输

敏感性

对热敏感

产品介绍

属呋喃香豆素类化合物。为棱柱状结晶（由乙醚）、长细针晶（由热水），易溶于氯仿，可溶于苯、乙醇、乙醚和苛性碱溶液，不溶于冷水。Imperatorin is a furocoumarin present in citrus fruits, which is used in HIV-1 research. Studies indicate that the transcription factor Sp1 is essential in the inhibitory functions of Imperatorin. In addition, Imperatorin inhibits cyclin D1 expression and stops the cell cycle at G1. These studies also suggest that Imperatorin suppresses HIV-1 replication in primary T lymphocytes and transformed cell lines. Furthermore, it has been suggested that the inhibitory effects of Imperatorin on HIV-1 at the transcriptional level can be monitored effectively in HeLa cells. Imperatorin can also cause apoptosis in human promyelocytic leukaemia, HL-60 via the cytochrome c/caspase-9 pathway. Imperatorin is a furocoumarin present in citrus fruits, which is used in HIV-1 research. Studies indicate that the transcription factor Sp1 is essential in the inhibitory functions of Imperatorin. In addition, Imperatorin inhibits cyclin D1 expression and stops the cell cycle at G1. These studies also suggest that Imperatorin suppresses HIV-1 replication in primary T lymphocytes and transformed cell lines. Furthermore, it has been suggested that the inhibitory effects of Imperatorin on HIV-1 at the transcriptional level can be monitored effectively in HeLa cells. Imperatorin can also cause apoptosis in human promyelocytic leukaemia, HL-60 via the cytochrome c/caspase-9 pathway.

生化机理

欧前胡素是p38、ERK路径的调控因子。欧前胡素增加BMP-2的表达(mRNA) ,体外研究证实欧前胡素增加体内骨质密度/体积和矿物化。细胞周期蛋白D1抑制剂。诱导细胞周期停滞在G1。激活胱天蛋白酶9并诱导凋亡。抑制HIV-1复制。TRPV1激动剂弱（EC 50 = 13μM）。显示出抗增殖作用。在体内显示镇痛作用。口服具有活性

CAS号

482-44-0(DMSO)

分子式

C16H14O4

分子量

270.28 g/mol

EC号

207-581-1

MDL号

PubChem SID: 504751913

PubChem编号

10212

Isomeric SMILES

CC(=CCOC1=C2C(=CC3=C1OC=C3)C=CC(=O)O2)C

IIUPAC Name

9-(3-methylbut-2-enoxy)furo[3,2-g]chromen-7-one

INCHI

1S/C16H14O4/c1-10(2)5-7-19-16-14-12(6-8-18-14)9-11-3-4-13(17)20-15(11)16/h3-6,8-9H,7H2,1-2H3

InChi Key

OLOOJGVNMBJLLR-UHFFFAOYSA-N

Smiles

CC(=CCOC1=C2C(=CC3=C1OC=C3)C=CC(=O)O2)C

PubChem SID

504751913

熔点

97.0 to 101.0 °C

氢键供体数Hydrogen Bond Donor Count

氢键受体数Hydrogen Bond Acceptor Count

可旋转键计数Rotatable Bond Count

精确质量Exact Mass

270.089 Da

单同位素质量Monoisotopic Mass

270.089 Da

拓扑极表面积Topological Polar Surface Area

48.700 Å²

重原子数Heavy Atom Count

形式电荷Formal Charge

复杂度Complexity

436.000

同位素原子数Isotope Atom Count

共价键合单元计数Covalently-Bonded Unit Count

XLogP3

3.400

Reaxy-Rn

249728

Merck Index

4925

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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