Share to

Details

Safety

Technical Documents

Articles

reviews

Consult

returns

Product details

名称

Iptacopan, 补体因子 B 抑制剂

分子类型

小分子

别名

4-((2S,4S)-4-乙氧基-1-((5-甲氧基-7-甲基-1H-吲哚-4-基)甲基)哌啶-2-基)苯甲酸 | 伊普塔科潘

英文别名

WHO 11259 | compound 41 [PMID: 32073845] | IPTACOPAN [WHO-DD] | Z56899081 | JGQ | US9682968, Example-26a | HY-127105 | SCHEMBL16400416 | EX-A5728 | SY039008 | GTPL10710 | 4-((2S,4S)-(4-ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl))ben

英文名称

Iptacopan

货号

I611135-5mg

包装规格

5mg

级别

Moligand™

浓度

≥98%

储存温度

-20°C储存

运输条件

超低温冰袋运输

生化机理

Iptacopan (LNP023) 是一种首创的，有效的，具有口服活性的高选择性的 factor B 抑制剂，IC50 值为 10 nM。Iptacopan 直接可逆且高亲和力结合 factor B，KD为 7.9 nM。Iptacopan 可靶向 C3 肾小球病的根本病因。

CAS号

1644670-37-0

分子式

C25H30N2O4

分子量

422.52 g/mol

PubChem编号

90467622

Isomeric SMILES

CCO[C@H]1CCN([C@@H](C1)C2=CC=C(C=C2)C(=O)O)CC3=C(C=C(C4=C3C=CN4)C)OC

IIUPAC Name

4-[(2S,4S)-4-ethoxy-1-[(5-methoxy-7-methyl-1H-indol-4-yl)methyl]piperidin-2-yl]benzoic acid

INCHI

1S/C25H30N2O4/c1-4-31-19-10-12-27(22(14-19)17-5-7-18(8-6-17)25(28)29)15-21-20-9-11-26-24(20)16(2)13-23(21)30-3/h5-9,11,13,19,22,26H,4,10,12,14-15H2,1-3H3,(H,28,29)/t19-,22-/m0/s1

InChi Key

RENRQMCACQEWFC-UGKGYDQZSA-N

Smiles

CCOC1CCN(C(C1)C2=CC=C(C=C2)C(=O)O)CC3=C(C=C(C4=C3C=CN4)C)OC

PubChem CID

90467622

关联CAS

1644670-37-0；1646321-63-2

氢键供体数Hydrogen Bond Donor Count

氢键受体数Hydrogen Bond Acceptor Count

可旋转键计数Rotatable Bond Count

精确质量Exact Mass

422.221 Da

单同位素质量Monoisotopic Mass

422.221 Da

拓扑极表面积Topological Polar Surface Area

74.800 Å²

重原子数Heavy Atom Count

形式电荷Formal Charge

复杂度Complexity

594

同位素原子数Isotope Atom Count

共价键合单元计数Covalently-Bonded Unit Count

XLogP3

1.8

ALogP

1.8

作用类型

抑制剂

作用机制

补体因子 B 抑制剂

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

user reviews

Consultation

Warm reminder：

Because the manufacturer may temporarily adjust product specifications, prices, inventory, parameters and other information without notice, and there are differences in each user's consultation time and procurement needs, the platform reply content is only of reference value within a certain period. Sorry for the inconvenience caused to you, and thank you for your understanding and support! Please consult the online customer service for the latest details. Everything is subject to the real-time reply of the customer service.！

After Sales Services

Please check the quantity, appearance and product information in time when you receive the goods. In case of damage, wrong delivery, abnormal quality and other problems, please feel free to contact us.

Service Hotline:400-6226-992 ，We will handle it for you as soon as possible, thank you for your support and trust.！