
- Treatment: 慢性暴露:通常需要肾透析来缓解尿毒症的症状,直到肾功能恢复正常。急性暴露:眼睛:用流动水冲洗打开的眼睛几分钟。摄入:不要催吐。用水漱口(切勿给失去知觉的人口服任何东西)。立即寻求医疗建议。
- Hazard summary: 刺激物;[PhytoTechnology Laboratories MSDS] 参见吲哚。参见吲哚-3-丁酸。
- exposure pathway: 内源性,摄入,皮肤接触(接触)
- Toxicity summary: 尿毒症毒素如吲哚-3-乙酸通过有机离子转运体(特别是OAT3)主动转运到肾脏。尿毒症毒素水平升高可刺激活性氧的产生。这似乎是通过尿毒症毒素直接结合或抑制NADPH氧化酶(特别是肾脏和心脏中丰富的NOX4)介导的(A7868)。活性氧可以诱导几种不同的DNA甲基转移酶(DNMTs),这些酶参与一种称为KLOTHO的蛋白质的沉默。KLOTHO已被确定为在抗衰老、矿物质代谢和维生素D代谢中具有重要作用。多项研究表明,在急性或慢性肾脏疾病期间,KLOTHO mRNA和蛋白质水平会降低,以回...
- Regulatory information: 新西兰 EPA 化学品状态清单: 吲哚-3-乙酸酸: 没有单独批准,但可在适当的团体标准下使用
- Health Effects: 吲哚乙酸在其MSDS中被列为可能对哺乳动物体细胞有致突变性。它也被确定为潜在的皮肤、眼睛和呼吸道刺激物,并警告用户不要摄入。急性接触吲哚乙酸可导致轻微的皮肤和眼睛刺激。慢性接触尿毒症毒素可导致多种疾病,包括肾损伤、慢性肾病和心血管疾病。高水平的吲哚乙酸与称为Hartnup病的先天代谢错误有关。
- ecotoxicity value: 美国农业部APHIS化学影响: collection=usda_chemeffect&query_type=synonym&query='^87-51-4$'
- Symptoms and Signs: 作为一种尿毒症毒素,这种化合物可引起尿毒症综合征。尿毒症综合征可能影响身体的任何部位,可导致恶心、呕吐、食欲不振和体重减轻。它还可引起精神状态改变,如意识混乱、意识降低、烦躁不安、精神病、癫痫和昏迷。也可能出现异常出血,如自发性出血或轻微损伤后大量出血。尿毒症综合征患者可能出现心脏问题,如心律不齐、心脏周围囊膜炎症(心包炎)和心脏压力增加。由于肺部和胸壁之间的积液(胸腔积液)导致的呼吸困难也可能出现。
- Hazard categories and classifications: STOT SE 3 (85.7%)
- Carcinogen Classification: 对人类无致癌性迹象(未被IARC列出)。
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indole-3-acetic acid 98%Biotechnology Grade 25g
indole-3-acetic acid 98%Biotechnology Grade 25g, Macklin, 87-51-4, complete specifications, for production, research, laboratory testing and inspection, digital one-stop procurement platform for scientific materials.




