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Product details

名称

IBR2

分子类型

小分子

英文名称

IBR2

货号

I646314-5mg

包装规格

5mg

浓度

≥98%

储存温度

-20°C储存

运输条件

超低温冰袋运输

产品介绍

IBR2 is a potent and specific RAD51 inhibitor and inhibits RAD51 -mediated DNA double-strand break repair. IBR2 disrupts RAD51 multimerization, accelerates proteasome-mediated RAD51 protein degradation, inhibits cancer cell growth and induces apoptosis In Vitro IBR2 shows interesting RAD51 inhibition activities. RAD51 is rapidly degraded in IBR2-treated cancer cells, and the homologous recombination repair is impaired, subsequently leading to cell death. The IC 50 values of the original IBR2 are in the range of 12-20 μM for most tested cancer cell lines. IBR2 can inhibit the growth of triple-negative human breast cancer cell line MBA-MD-468 with an IC 50 of 14.8 μM. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:RAD51

生化机理

IBR2 是一种强效的特异性 RAD51 抑制剂，可抑制 RAD51 介导的 DNA 双链断裂修复。IBR2 能破坏 RAD51 的多聚化，加速蛋白酶体介导的 RAD51 蛋白降解，抑制癌细胞生长并诱导细胞凋亡 [1

CAS号

313526-24-8

分子式

C24H20N2O2S

分子量

400.5 g/mol

PubChem编号

4664423

Isomeric SMILES

C1=CC=C(C=C1)CS(=O)(=O)N2C=CC3=CC=CC=C3C2C4=CNC5=CC=CC=C54

IIUPAC Name

2-benzylsulfonyl-1-(1H-indol-3-yl)-1H-isoquinoline

INCHI

1S/C24H20N2O2S/c27-29(28,17-18-8-2-1-3-9-18)26-15-14-19-10-4-5-11-20(19)24(26)22-16-25-23-13-7-6-12-21(22)23/h1-16,24-25H,17H2

InChi Key

YCOHEPDJLXZVBZ-UHFFFAOYSA-N

Smiles

C1=CC=C(C=C1)CS(=O)(=O)N2C=CC3=CC=CC=C3C2C4=CNC5=CC=CC=C54

PubChem CID

4664423

溶解性

DMSO : ≥ 100 mg/mL (249.69 mM)

氢键供体数Hydrogen Bond Donor Count

氢键受体数Hydrogen Bond Acceptor Count

可旋转键计数Rotatable Bond Count

精确质量Exact Mass

400.125 Da

单同位素质量Monoisotopic Mass

400.125 Da

拓扑极表面积Topological Polar Surface Area

61.600 Å²

重原子数Heavy Atom Count

形式电荷Formal Charge

复杂度Complexity

694

同位素原子数Isotope Atom Count

共价键合单元计数Covalently-Bonded Unit Count

XLogP3

4.5

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

user reviews

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