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名称

IMP-1088

分子类型

未知

英文名称

IMP-1088

货号

I647608-5mg

包装规格

5mg

浓度

≥98%

储存温度

-20°C储存

运输条件

超低温冰袋运输

产品介绍

IMP-1088 is a potent human N-myristoyltransferases NMT1 and NMT2 dual inhibitor with IC 50 s of In Vitro IMP-1088 (1-1000 nM) prevents virus-induced cytopathic effect (CPE) in a dose-dependent manner with an IC 50 of 17 nM. IMP-1088 (125 nM) complete suppresses of new infectious virus with an IC 50 of 5.8 nM. IMP-1088 (1-1000 nM) blocks production of infectious virus and inhibits single cycle replication in primary human bronchial epithelial cells (hBEC) infected with rhinovirus RV-A1 (MOI 5) for 7 h. IMP-1088 significantly inhibits production of infectious virus even when added up to 3 hours post-infection. IMP-1088 (50 nM) significantly less enriches multiple N-myristoylated proteins in enriched samples. IMP-1088 (500 nM) inhibits production of infectious rhinovirus particles by blocking virus assembly in HeLa cells infected with rhinovirus RV-A16 (MOI 20) for 6 h. IMP-1088 (0.24 nM-1 µM; for 24 hours +24 hours washout) has no long-term effect on cell viability and NMT activity fully recovers by 24 h. IMP-1088 potently blocks a key step in viral capsid assembly by inhibition of co-translational myristoylation of a specific virus-encoded protein (VP0). IMP-1088 blocks neither production of viral RNA, nor translation of rhinovirus polyprotein. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Liquid IC50& Target:IC50:

生化机理

IMP-1088 是一种强效的人类 N-肉豆蔻酰转移酶 NMT1 和 NMT2 双重抑制剂，对 HsNMT1 和 HsNMT2 的 IC 50 s 均小于 1 nM。IMP-1088 对 HsNMT1 的 K d 小于 210 pM。IMP-1088 通过阻断鼻病毒编码的鼻病毒基因，有效阻断鼻病毒的复制。

CAS号

2059148-82-0

分子式

C25H29F2N5O

分子量

453.53 g/mol

PubChem编号

132274735

Isomeric SMILES

CC1=C(C(=NN1C)C)CCOC2=C(C=CC(=C2F)F)C3=CC4=C(C=C3)N(N=C4CN(C)C)C

Smiles

CC1=C(C(=NN1C)C)CCOC2=C(C=CC(=C2F)F)C3=CC4=C(C=C3)N(N=C4CN(C)C)C

PubChem CID

132274735

溶解性

DMSO : 100 mg/mL (220.49 mM; Need ultrasonic)

氢键供体数Hydrogen Bond Donor Count

氢键受体数Hydrogen Bond Acceptor Count

可旋转键计数Rotatable Bond Count

精确质量Exact Mass

453.234 Da

单同位素质量Monoisotopic Mass

453.234 Da

拓扑极表面积Topological Polar Surface Area

48.100 Å²

重原子数Heavy Atom Count

形式电荷Formal Charge

复杂度Complexity

642.000

同位素原子数Isotope Atom Count

共价键合单元计数Covalently-Bonded Unit Count

XLogP3

4.300

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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