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Product introduction

IRE1α kinase-IN-2 is a potent IRE1α kinase inhibitor, with an EC 50 of 0.82 μM. IRE1α kinase-IN-2 inhibits IRE1α kinase autophosphorylation (IC 50 =3.12 μM). IRE1α kinase-IN-2 inhibits XBP1 mRNA splicing in the WT cell lines. In Vitro IRE1α kinase-IN-2 (compound 3) inhibits XBP1 mRNA splicing, even during ER stress. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid

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Chinese name

IRE1α kinase-IN-2

English name

IRE1α kinase-IN-2

Chinese alias

IRE1α激酶-IN-2

English alias

CAS number

1414938-21-8

molecular formula

C27H23F3N6O

molecular weight

504.51 g/mol

Exact mass

≥98%

PSA

Logp

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